gene 940 words KG: CALR 2026-03-22
kind:genesection:genesstate:published
Contents

CALR Gene

🧬 Gene Info
Gene SymbolCALR
Full NameCalreticulin
Chromosome19p13.2
FunctionCalreticulin performs several essential cellular functions:
Subcellular Localizationthe endoplasmic reticulum (ER). Calreticulin is essential for calcium homeostasis, protein quality control, and cellular
Molecular Weight48 kDa
Amino Acids417 aa
PathwaysPyroptosis
UniProt ID[P27797](https://www.uniprot.org/uniprot/P27797)
Ensembl IDENSG00000179218
GeneCardsCALR
Human Protein AtlasCALR
Associated DiseasesALS, Ms, Tumor, dementia, frontotemporal, neurodegeneration
InteractionsGSDME, RIPK1, TNFSF10, PAH, CANX, PYCARD
KG Connections69 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (7)

Gamma entrainment therapy to restore hippocampal-cortical sy
Score: 0.68
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Complement C1q Mimetic Decoy Therapy
Score: 0.48
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45
Complement C1q Subtype Switching
Score: 0.44

Related Analyses (6)

4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (8)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: activates
Packard Center for ALS Research
institution · KG edge: expressed_in
GSDME — Gasdermin E
gene · KG edge: activates
CTSD — Cathepsin D
gene · KG edge: associated_with
CANX — Calnexin
gene · KG edge: inhibits

Knowledge Graph (12 edges)

CALR provides_data_for ds-83b31ef18d49
CALR activates GSDME
CALR associated_with S100A6
CALR expressed_in AKT
CALR associated_with PRDX5
CALR associated_with CTSD
CALR regulates BCL2
CALR inhibits RIPK1
CALR activates TNFSF10
CALR activates PAH