gene 1,559 words KG: ELAVL1
Contents

ELAVL1 Gene

🧬 Gene Info
Gene SymbolELAVL1
Chromosome19p13.2
Protein TypeGene
Functionis a member of the ELAV (Embryonic Lethal Abnormal Vision) family of RNA-binding proteins.
Primary Expressionneurons throughout the central and peripheral nervous systems:
Subcellular Localizationand RNA binding activity[@lee2020]
Molecular Weight36 kDa
Amino Acids326 aa
Exons10
PathwaysAutophagy, Ferroptosis, Proteasome, Ubiquitin-Proteasome
GeneCardsELAVL1
Human Protein AtlasELAVL1
PhosphorylationBy multiple kinases including Chk2, PKC, and CDK1, affecting its subcellular localization and RNA binding activity[@lee2020]
MethylationArginine methylation by PRMT1 modulates RNA binding affinity
Associated DiseasesCarcinoma, Hepatocellular Carcinoma, Tumor
InteractionsACTB, AND, ATF3, ATG, AUTOPHAGY, BECLIN1
SciDEX HypothesesCompensatory RBP Expression Therapy
KG Connections108 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (2)

RNA-Binding Protein Sequestration and 3′UTR Dysregulation
Score: 0.62
Compensatory RBP Expression Therapy
Score: 0.00

Knowledge Graph (12 edges)

NSUN2 activates ELAVL1
YBX1 interacts_with ELAVL1
SQSTM1 associated_with ELAVL1
TNF associated_with ELAVL1
ELAVL1 associated_with GPX4
ELAVL1 associated_with SLC7A11
ELAVL1 associated_with FTH1
ELAVL1 associated_with P62
ELAVL1 associated_with MAP1LC3A
ELAVL1 associated_with PTGS2

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