| Gene Symbol | GRIN2B |
| Full Name | NMDA Receptor Subunit 2B |
| Protein Type | Gene |
| Function | The GRIN2B subunit contributes to the unique pharmacological and biophysical properties of NMDA receptors |
| Primary Expression | Prefrontal Cortex, Cortex, Ventral Tegmental Area, Substantia Nigra |
| Pathways | Circadian Rhythm, Calcium Signaling, Epigenetic, synaptic plasticity |
| GeneCards | GRIN2B |
| Human Protein Atlas | GRIN2B |
| Calcium Permeability | NMDA receptors containing GRIN2B have high calcium permeability, enabling calcium-dependent signaling cascades essential for synaptic plasticity[@paoletti2013] |
| Slower Kinetics | GRIN2B-containing receptors have slower deactivation kinetics compared to GRIN2A-containing receptors |
| Developmental Regulation | GRIN2B expression peaks early in development and decreases with age as GRIN2A expression increases |
| Synaptic Localization | GRIN2B is primarily found at extrasynaptic and immature synapses |
| Synaptic Dysfunction | Aβ oligomers directly interact with NMDA receptors, causing internalization and impairment of glutamatergic signaling[@liu2021] |
| Excitotoxicity | Overactivation of NMDA receptors contributes to dopaminergic neuron death |
| Memory Deficits | NMDA receptor hypofunction, particularly involving GRIN2B, correlates with cognitive deficits in AD |
| Associated Diseases | Als, Alzheimer, Bipolar, Bipolar Disorder, Depression |
| Interactions | Albumin, DAO, DISC1, Fyn, G72, GRM3 |
| SciDEX Hypotheses | GluN2B-Mediated Thalamocortical Control of Glympha Cortico-Striatal Synchrony Restoration via NMDA Mo Thalamocortical Synchrony Restoration via NMDA Mod (+7 more) |
| KG Connections | 202 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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