| Gene Symbol | HDAC1 |
| Chromosome | 1p35.2-p35.1<br> |
| Function | HDAC1 functions as a transcriptional repressor by deacetylating histone H3 and H4 tails, leading to chromatin compaction and reduced gene expression. |
| Primary Expression | the brain with high levels in: - Hippocampus (CA1-CA3 pyramidal neurons) - Cerebral cortex (lay |
| Molecular Weight | 55 kDa |
| Pathways | NF-κB |
| UniProt ID | Q13547 |
| NCBI Gene ID | 3065 |
| Ensembl ID | ENSG00000100994 |
| GeneCards | HDAC1 |
| Human Protein Atlas | HDAC1 |
| Chromatin Compaction | Deacetylates histones to promote heterochromatin formation |
| Transcriptional Repression | Part of Sin3A, CoREST, and NuRD complexes |
| Cell Cycle Regulation | Controls expression of cell cycle regulators |
| DNA Damage Response | Regulates DNA repair gene expression |
| Associated Diseases | Alzheimer, disease, synaptic dysfunction |
| Known Drugs/Compounds | BORTEZOMIB, butyrate |
| Interactions | AKT, AND, APOPTOSIS, App, AUTOPHAGY, BCL-2 |
| SciDEX Hypotheses | Microglial Priming Window for HDAC1-Dependent DAM Epigenetic Silencing of SPP1 in Disease-Associated HDAC/MITF Epigenetic Reprogramming of Microglia (+1 more) |
| KG Connections | 337 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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