| Gene Symbol | MBP |
| Full Name | Myelin Basic Protein |
| Chromosome | 18q23 |
| Function | Membrane compaction: MBP interacts with the cytoplasmic surface of the oligodendrocyte membrane, facilitating the tight apposition of myelin lamellae [6] |
| Primary Expression | a developmentally regulated manner, with different isoforms predominant at different stages of oligodendrocyte maturation and myelination |
| Subcellular Localization | and interaction with other myelin proteins. The 18.5 kDa isoform is the most abundant in adult human brain and is the pr |
| Molecular Weight | 21.5 kDa |
| Amino Acids | 197 aa |
| Exons | 11 |
| Pathways | MAPK |
| Ensembl ID | ENSG00000197971 |
| GeneCards | MBP |
| Human Protein Atlas | MBP |
| Signal transduction | MBP can be phosphorylated, suggesting roles in cell signaling |
| Calcium homeostasis | MBP influences calcium signaling in oligodendrocytes |
| Associated Diseases | Als, Alzheimer, Alzheimer disease, dementia, Ms |
| Known Drugs/Compounds | metformin |
| Interactions | ACHE, ACSL4, AGING, AKT, ALZHEIMER, ALZHEIMER'S DISEASE |
| SciDEX Hypotheses | Myelin Breakdown-Amyloid Interaction Amplifies Cor Cross-Modal Integration Hypothesis |
| KG Connections | 439 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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