| Gene Symbol | PLP1 |
| Protein Family | Proteolipid protein family |
| Function | PLP1 is essential for multiple aspects of CNS myelination: |
| Primary Expression | CNS (not PNS) |
| Subcellular Localization | Myelin sheath, oligodendrocyte plasma membrane |
| Molecular Weight | 30 kDa |
| Amino Acids | 35 aa |
| Pathways | Phagocytosis |
| UniProt ID | [P60228](https://www.uniprot.org/uniprot/P60228) |
| GeneCards | PLP1 |
| Human Protein Atlas | PLP1 |
| Prenatal | Low expression in oligodendrocyte progenitor cells |
| Postnatal | Dramatic increase during active myelination (first 3-6 months in humans) |
| Adult | Sustained expression for myelin maintenance |
| Regional | Highest expression in cerebral white matter, corpus callosum, internal capsule, and spinal cord |
| Associated Diseases | ALS, Alzheimer, Ms, Parkinson, Pelizaeus-Merzbacher disease, dementia |
| Known Drugs/Compounds | RESVERATROL, CURCUMIN |
| Interactions | MBP, HSPA1A, GFAP, ST3GAL5, MAG, OLIG1 |
| KG Connections | 169 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |