gene 607 words KG: NFKB1
Contents

NFKB1 Gene

🧬 Gene Info
Gene SymbolNFKB1
Full NameNuclear Factor Kappa B Subunit 1
Chromosome4q24
Protein FamilyNF-κB transcription factors
Protein TypeTranscription Factor
FunctionNFKB1 encodes p105, which is processed to p50, a DNA-binding subunit of NF-κB.
Molecular Weight105 kDa (p105), 50 kDa (p50)
Amino Acids968 aa
PathwaysNfkb, NFKB, NF-κB, NF-κB pathway
UniProt IDP19838
NCBI Gene ID4790
Ensembl IDENSG00000109320
OMIM164011
GeneCardsNFKB1
Human Protein AtlasNFKB1
Associated DiseasesAls, Alzheimer, Alzheimer'S Disease, Cancer, Carcinoma
Known Drugs/CompoundsBerberine, Electroacupuncture, Xiyangshen Sanqi Danshen Granules
InteractionsALZHEIMER, ALZHEIMER DISEASE, ALZHEIMER'S DISEASE, AMPK, AMYLOID, ANG
SciDEX HypothesesDual NF-κB/MMP Inhibition Strategy
Inflammaging-Epigenome Decoupling Strategy
KG Connections417 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (18)

Astrocyte C3aR Signaling as Bifurcation Point for A1/A2 Fate
Score: 0.75
Complement-SASP Amplification Cascade as Mechanistic Link
Score: 0.74
TLR4/MyD88/NF-κB Axis Blockade to Interrupt LPS-Mediated Gut
Score: 0.70
SASP Modulation Rather Than Cell Elimination
Score: 0.66
C3aR Blockade Disrupts the Microglial-Astrocyte Feedforward
Score: 0.65
Intestinal Permeability Defects → Systemic LPS Translocation
Score: 0.63
LPS-TLR4-NF-κB Signaling Cascade as Therapeutic Target
Score: 0.62
Female microglia exhibit heightened complement gene expressi
Score: 0.61
Aryl Hydrocarbon Receptor (AhR) Activation by Microbiome Met
Score: 0.60
Microglial Priming via NF-κB-Dependent DAM Phenotype and Com
Score: 0.58
Dual NF-κB/MMP Inhibition Strategy
Score: 0.55
Perinatal Hypoxia-Primed Microglia Targeting
Score: 0.55
Selectively Inhibit Maladaptive AQP4-Driven Astrocyte-Microg
Score: 0.50
A lower-dose 50-100 mg/day glial anti-inflammatory effect ma
Score: 0.48
Inflammaging-Epigenome Decoupling Strategy
Score: 0.00
Nrf2-NF-κB Oscillatory Circuit Modulation
Score: 0.00
Gut Barrier Reconstruction via Polysaccharide-Probiotic Synb
Score: 0.00
Epigenetic Clock Biomarker-Guided Combination Therapy
Score: 0.00

Knowledge Graph (12 edges)

hyperoxia activates NFKB1
TNF activates NFKB1
TRAF6 activates NFKB1
NFKB1 regulates TNF
NFKB1 regulates IL1B
NFKB1 therapeutic_target TRIM24
NFKB1 therapeutic_target TDP1
NFKB1 therapeutic_target MAPK1
NFKB1 therapeutic_target CTSD
NFKB1 therapeutic_target HIF1A

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