pathway

Nf-Kb

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Nf-Kb: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1604Connections

0Hypotheses

0Analyses

34Outgoing

50Incoming

Summary

Nf-Kb is a biological pathway involved in neurodegeneration research. Key relationships include: activates, regulates, associated with. Associated with Aging, Als, Alzheimer. Connected to 290 entities in the SciDEX knowledge graph.

View on Wiki →

🔀 Pathway Info

Name	Nf-Kb
Key Genes/Proteins	TNF, NF-KB, TNF-Α, CYTOKINES, CANCER, NEUROINFLAMMATION
Related Diseases	Inflammation, Cancer, Neuroinflammation

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    NF_KB(["NF-KB"])
    Nf_Kb["Nf-Kb"]
    Inflammation["Inflammation"]
    TNF__(["TNF-Alpha"])
    TNF(["TNF"])
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    APOPTOSIS(["APOPTOSIS"])
    NEURODEGENERATION(["NEURODEGENERATION"])
    MICROGLIA["/"MICROGLIA"/"]
    NEUROINFLAMMATION["NEUROINFLAMMATION"]
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    AKT(["AKT"])
    CANCER(["CANCER"])

    NF_KB -->|"activates"| Nf_Kb
    NF_KB -->|"activates"| Inflammation
    NF_KB -->|"activates"| TNF__
    NF_KB -->|"associated with"| TNF
    NF_KB -->|"associated with"| PARKINSON_S_DISEASE
    NF_KB -->|"associated with"| OXIDATIVE_STRESS
    TNF -->|"activates"| NF_KB
    APOPTOSIS -->|"associated with"| NF_KB
    NEURODEGENERATION -->|"associated with"| NF_KB
    MICROGLIA -->|"associated with"| NF_KB
    NEUROINFLAMMATION -->|"associated with"| NF_KB
    ALZHEIMER_S_DISEASE -->|"associated with"| NF_KB
    AKT -->|"associated with"| NF_KB
    NF_KB -->|"regulates"| Nf_Kb
    NF_KB -->|"activates"| CANCER

    style NF_KB fill:#006494,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (732)

Target	Relation	Type	Str
Autophagy	interacts_with	pathway	0.55
Mapk	interacts_with	pathway	0.55
Apoptosis	interacts_with	pathway	0.55
disease	activates	disease	0.50
ALZHEIMER'S	activates	concept	0.50
disease	associated_with	disease	0.50
ALZHEIMER'S	associated_with	concept	0.50
CURCUMIN	regulates	concept	0.50
RESVERATROL	regulates	concept	0.50
PROINFLAMMATORY CYTOKINES	activates	concept	0.50
Proteins	activates	protein	0.50
GLIOSIS	activates	concept	0.50
Neuroprotection	activates	process	0.50
Neuroinflammatory	regulates	pathway	0.50
DOPAMINERGIC	regulates	concept	0.50
Nlrp3 Inflammasome	regulates	pathway	0.50
DOPAMINE	regulates	concept	0.50
Neuron	regulates	cell_type	0.50
Microglia	therapeutic_target	cell_type	0.50
T Cell	therapeutic_target	cell_type	0.50
Astrocyte	therapeutic_target	cell_type	0.50
Neuron	therapeutic_target	cell_type	0.50
Stem Cell	activates	cell_type	0.50
Osteoblast	activates	cell_type	0.50
Macrophage	activates	cell_type	0.50
Stem Cell	associated_with	cell_type	0.50
Microglia	associated_with	cell_type	0.50
Neuron	associated_with	cell_type	0.50
Microglia	activates	cell_type	0.50
Fibroblast	activates	cell_type	0.50
Neuron	activates	cell_type	0.50
Astrocyte	activates	cell_type	0.50
Dopaminergic	regulates	cell_type	0.50
Neuron	inhibits	cell_type	0.50

Incoming (872)

Source	Relation	Type	Str
TNF	activates	gene	1.00
NF-KB	activates	gene	1.00
TNF-Α	activates	gene	1.00
Inflammation	regulates	disease	1.00
NF-KB	regulates	gene	1.00
CYTOKINES	activates	gene	1.00
Inflammation	activates	disease	1.00
Cancer	activates	disease	0.90
CANCER	activates	gene	0.90
NF-KB	inhibits	gene	0.90
NEUROINFLAMMATION	activates	gene	0.90
INFLAMMATION	regulates	gene	0.90
Neuroinflammation	activates	disease	0.90
GENES	regulates	gene	0.80
Cancer	regulates	disease	0.80
NEURODEGENERATION	therapeutic_target	gene	0.80
NF-ΚB	regulates	gene	0.80
NEURODEGENERATION	activates	gene	0.80
AKT	activates	gene	0.80
Neurodegeneration	activates	disease	0.80
NF-KB	associated_with	gene	0.80
IL-6	activates	gene	0.80
Als	associated_with	disease	0.80
Als	therapeutic_target	disease	0.80
MICRORNAS	regulates	gene	0.70
MIRNAS	regulates	gene	0.70
IL6	activates	gene	0.70
TNF	regulates	gene	0.70
AKT	regulates	gene	0.70
PI3K	regulates	gene	0.70
BAX	activates	gene	0.70
NRF2	activates	gene	0.70
ALZHEIMER'S DISEASE	therapeutic_target	gene	0.70
NF-ΚB	therapeutic_target	gene	0.70
NEUROINFLAMMATION	therapeutic_target	gene	0.70
NF-ΚB	activates	gene	0.70
APOPTOSIS	activates	gene	0.70
INFLAMMATION	activates	gene	0.70
STAT3	activates	gene	0.70
OXIDATIVE STRESS	activates	gene	0.70
BCL-2	activates	gene	0.70
TLR4	regulates	gene	0.70
MICROGLIA	inhibits	gene	0.70
JUN	activates	gene	0.70
Als	expressed_in	disease	0.70
DNA	regulates	gene	0.70
Infection	activates	disease	0.70
PI3K	activates	gene	0.70
ROS	activates	gene	0.70
CANCER	regulates	gene	0.70

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Nf-Kb

Understanding Entity Pages

Summary

Wiki Pages (21)

nf-kb

CBS/PSP Supplements Guide

GSK-3β in Neurodegeneration

TREM2 Microglial Signaling Pathway in Neurodegeneration

omega-3-fatty-acids-neurodegeneration

Melatonin for Tauopathy: Comprehensive Evidence Synthesis

Rapamycin ALS Trial - mTOR Inhibition for Amyotrophic Lateral Sclerosis

Coenzyme Q10 for Neurodegeneration

Spinal Cord Dorsal Horn Neurons

nlrc5-protein

vitamin-d-therapy-neurodegeneration

NACET (N-Acetylcysteine Ethyl Ester)

Gene-Mechanism-Therapy Causal Chains

Curcumin for Neurodegeneration

creatine-supplementation-neurodegeneration

Neuroinflammation-Mitochondria Crosstalk Pathway

Epigenetic-Metabolic Coupling: SIRT1 Activator + NAD+ Precursor

NF-kB Signaling Pathway in Neurodegeneration

DDX3X Gene