| Gene Symbol | SNCA |
| Full Name | Alpha-Synuclein |
| Chromosome | 4q22.1 |
| Protein Type | Structural Protein |
| Target Class | Structural Protein |
| Function | Immunotherapy targeting alpha-synuclein aggregates or small molecules preventing aggregation |
| Mechanism of Action | Immunotherapy targeting alpha-synuclein aggregates or small molecules preventing aggregation |
| Primary Expression | Substantia nigra, Cerebral cortex, Presynaptic terminals |
| Druggability | Medium (0.49) |
| Clinical Stage | Phase II |
| Pathways | Akt, Alpha-Synuclein, Autophagy, Cell Cycle, Epigenetic |
| UniProt ID | P37840 |
| NCBI Gene ID | 6622 |
| Ensembl ID | ENSG00000145335 |
| OMIM | 163890 |
| GeneCards | SNCA |
| Human Protein Atlas | SNCA |
| Associated Diseases | AD, Aging, ALI, Alpha-Synucleinopathies, Als |
| Known Drugs/Compounds | ACI-7104.056, AFFITOPE PD01A, ASO, Cinpanemab, D-520, levodopa |
| Interactions | ABCA7, ABCD3, ACETYL-COA, ACLY, aco2, ACO2 |
| SciDEX Target | View Target Profile (8 clinical trials) |
| SciDEX Hypotheses | SNCA conformer propagation across PD, DLB, and MSA Exosomal SNCA Propagation from Lysosome-Compromise SNCA Aggregation Hijacks the Endosomal Sorting Com (+8 more) |
| KG Connections | 2840 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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