gene 1,687 words KG: ent-gene-6d4506f6
Contents

A2M Gene

🧬 Gene Info
Gene SymbolA2M
Chromosome12p13.31 (human)
Protein Familyα2-macroglobulin family
FunctionThe protein possesses a unique "trap" mechanism
Molecular Weight~720 kDa (tetramer)
Amino Acids1450 amino acids
UniProt IDP01023
NCBI Gene ID2
GeneCardsA2M
Human Protein AtlasA2M
Associated DiseasesAD, Als, Alzheimer, Alzheimer's disease, AMI, Depression
InteractionsALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, APH1B, APOE, APOPTOSIS
KG Connections110 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (25)

PARP1 Inhibition Therapy
Score: 0.74
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
Glial Glycocalyx Remodeling Therapy
Score: 0.65
APOE4-Selective Lipid Nanoemulsion Therapy
Score: 0.74
APOE Isoform Conversion Therapy
Score: 0.72
← Prevpg 2/2

Related Analyses (6)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed
Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived

See Also (15)

APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: interacts_with
Accelerating Medicines Partnership for Alzheimer's Dise
institution · KG edge: implicated_in
APH1B Gene - Anterior Pharynx Defective 1 Homolog B
gene · KG edge: interacts_with
APOE contributes to Alzheimer's disease by regulating b
hypothesis · KG edge: interacts_with
Packard Center for ALS Research
institution · KG edge: associated_with

Knowledge Graph (2 edges)

ent-gene-6d4506f6 data_in benchmark_ot_ad_answer_key:A2M
benchmark_ot_ad_answer_key:A2M data_in ent-gene-6d4506f6

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