gene 797 words KG: CXCL12 2026-03-23
kind:genesection:genesstate:published
Contents

CXCL12 Gene

🧬 Gene Info
Gene SymbolCXCL12
Full NameCXCL12
Protein TypeGene
FunctionCXCL12 is a highly conserved chemokine expressed throughout the central nervous system.
Primary Expressionthe brain: - Neurons: High expression in cortex, hippocampus, cerebell
PathwaysApoptosis, Autophagy, Cell Cycle, Chaperone, Epigenetic
UniProt IDP48061
NCBI Gene IDSearch NCBI
GeneCardsCXCL12
Human Protein AtlasCXCL12
Associated DiseasesALS, Alzheimer, Cancer, Carcinoma, Depression
InteractionsEGFR, CXCR4, IL6, CTSD, CXCL8, GRM2
KG Connections190 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (12)

CYP46A1 Overexpression Gene Therapy
Score: 0.63
SASP-Driven Aquaporin-4 Dysregulation
Score: 0.59
Glymphatic System-Enhanced Antibody Clearance Reversal
Score: 0.54
Aquaporin-4 Polarization Rescue
Score: 0.51
Microglial Efferocytosis Enhancement via GPR32 Superagonists
Score: 0.48

Related Analyses (6)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived

See Also (14)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: activates
Packard Center for ALS Research
institution · KG edge: activates
Alzheimer Indonesia
institution · KG edge: interacts_with
CNR2 Gene - Cannabinoid Receptor 2 (CB2)
gene · KG edge: associated_with
CEBPB Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

CXCL12 provides_data_for ds-83b31ef18d49
CXCL12 activates EGFR
CXCL12 expressed_in SRC
CXCL12 expressed_in CD38
CXCL12 expressed_in CIITA
CXCL12 inhibits CXCR4
CXCL12 interacts_with CXCR4
CXCL12 associated_with FOXM1
CXCL12 activates IL6
CXCL12 associated_with NR1H3