gene

adamts4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about adamts4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

34Connections

0Hypotheses

0Analyses

5Outgoing

5Incoming

No summary available yet. View on Wiki →

🧬 Gene Info

Gene Symbol	ADAMTS4
Protein Type	Protease
Function	ADAMTS4 encodes a member of the ADAMTS (A Disintegrin And Metalloproteinase with Thrombospondin motifs) family of secreted zinc metalloproteinases.
Subcellular Localization	Secreted enzyme; localized to the extracellular space and cell surface
Exons	8
Pathways	Circadian Rhythm, Tgf-Β, TGF-beta signaling
Ensembl ID	ENSG00000158859
GeneCards	ADAMTS4
Human Protein Atlas	ADAMTS4
Associated Diseases	Alzheimer's Disease (AD
Interactions	BMAL1, SMAD3
KG Connections	5 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (4)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    ADAMTS4["ADAMTS4"]
    ADAMTS4 -->|"inhibits"| FBN1["FBN1"]
    ADAMTS4 -->|"activates"| Aging["Aging"]
    ADAMTS4 -->|"activates"| Ms["Ms"]
    ADAMTS4 -->|"activates"| SMAD3["SMAD3"]
    ADAMTS4 -->|"activates"| Circadian_Rhythm["Circadian Rhythm"]
    ADAMTS4 -->|"activates"| Tgf__["Tgf-Beta"]
    ADAMTS4 -->|"activates"| BMAL1["BMAL1"]
    BMAL1 -->|"inhibits"| ADAMTS4
    SMAD3 -->|"activates"| ADAMTS4
    AGING["AGING"] -->|"activates"| ADAMTS4

Outgoing (29)

Target	Relation	Type	Str
BMAL1	activates	protein	0.50
ENDOTHELIAL	activates	concept	0.50
EXTRACELLULAR MATRIX	activates	concept	0.50
SMAD3	activates	gene	0.50
Tgf-Β	activates	pathway	0.50

Incoming (5)

Source	Relation	Type	Str
BMAL1	inhibits	gene	0.64
BMAL1	activates	gene	0.60
SMAD3	activates	gene	0.60
ADAM10	interacts_with	gene	0.60
AGING	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

adamts4

Understanding Entity Pages

Wiki Pages (4)

ADAMTS4 Gene

ADAMTS-4 Protein