gene 916 words KG: ADNP 2026-03-24
kind:genesection:genesstate:published
Contents

ADNP Gene

🧬 Gene Info
Gene SymbolADNP
Protein TypeTranscription Factor
FunctionADNP encodes a 1,102 amino acid protein containing a homeobox domain, nine zinc fingers, and a PxVxL motif that mediates interaction with the SWI/SNF chromatin remodeling complex through HP1.
Molecular Weight124 kDa
Amino Acids102 aa
PathwaysAutophagy, Epigenetic, Wnt
Ensembl IDENSG00000101126
GeneCardsADNP
Human Protein AtlasADNP
Associated DiseasesAging, Ms, autism spectrum disorder
InteractionsSIRT1, TAU, LC3, P2X7, SNF, SWI
KG Connections85 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (17)

Synaptic Vesicle Tau Capture Inhibition
Score: 0.64
Trans-Synaptic Adhesion Molecule Modulation
Score: 0.64
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.88
CYP46A1 Overexpression Gene Therapy
Score: 0.86
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82

Related Analyses (6)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Epigenetic reprogramming in aging neurons
neurodegeneration · archived

See Also (9)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: causes
Packard Center for ALS Research
institution · KG edge: activates
Alzheimer Indonesia
institution · KG edge: activates
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: protects_against
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: interacts_with

Knowledge Graph (12 edges)

ADNP associated_with BECN1
ADNP interacts_with SIRT1
ADNP associated_with LC3
ADNP interacts_with TAU
ADNP interacts_with LC3
ADNP inhibits P2X7
ADNP associated_with HDAC2
ADNP associated_with YY1
ADNP activates schizophrenia
ADNP protects_against APP

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