gene 2,958 words KG: AKT2 2026-03-23
kind:genesection:genesstate:published
Contents

AKT2 Gene

🧬 Gene Info
Gene SymbolAKT2
Full NameAKT Serine/Threonine Kinase 2
Chromosome19q13.2
Protein TypeKinase
Functionis a crucial signaling molecule in the PI3K/AKT signaling pathway that plays essential roles in cell survival, metabolism, and neuronal function.
Primary ExpressionBrain (widespread), Muscle, Liver, Adipose tissue
Exons13
PathwaysAkt, Apoptosis, Autophagy, Immune Response, Mitophagy
UniProt IDP31751
NCBI Gene ID207
Ensembl IDENSG00000105221
OMIM164731
GeneCardsAKT2
Human Protein AtlasAKT2
Associated DiseasesALS, Aging, Atherosclerosis, Cancer, Cardiovascular
InteractionsTFE3, TFEB, UBIQUITIN, PI3K, APP, VEGF
KG Connections101 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (8)

Transcriptional Autophagy-Lysosome Coupling
Score: 0.66
The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction
Score: 0.40
TFEB-PGC1α Mitochondrial-Lysosomal Decoupling
Score: 0.40
CYP46A1 Overexpression Gene Therapy
Score: 0.63
APOE-Dependent Autophagy Restoration
Score: 0.61

Related Analyses (4)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (9)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: regulates
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: associated_with
Packard Center for ALS Research
institution · KG edge: implicated_in
Alzheimer Indonesia
institution · KG edge: activates
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: activates

Knowledge Graph (12 edges)

AKT2 associated_with AKT1
AKT2 activates TFE3
AKT2 therapeutic_target SIRT5
AKT2 activates TFEB
AKT2 activates UBIQUITIN
AKT2 regulates MUL1
AKT2 associated_with AKT
AKT2 implicated_in OVERVIEW
AKT2 associated_with AKT3
AKT2 inhibits PI3K