gene 1,995 words KG: ANT2 2026-03-27
kind:genesection:genesstate:published
Contents

ANT2 (Adenine Nucleotide Translocator 2)

🧬 Gene Info
Gene SymbolSLC25A5
Full NameAdenine Nucleotide Translocator 2 (ANT2)
ChromosomeXq26.3
Functionis a mitochondrial inner membrane protein that catalyzes the exchange of ADP and ATP across the inner mitochondrial membrane.
Primary Expressionmost tissues, including the brain
Molecular Weight33 kDa
Amino Acids322 aa
UniProt IDP02724
NCBI Gene ID291
Ensembl IDENSG00000148218
OMIM300120
GeneCardsSLC25A5
Human Protein AtlasSLC25A5
Protein NameAdenine Nucleotide Translocator 2 (ANT2)
Alternative NamesADP/ATP Translocase 2, ANT2, PiC (phosphate carrier) partner
Associated DiseasesChronic Kidney Disease, Nonalcoholic Fatty Liver Disease, Obesity
InteractionsMTOR, TFEB, INFLAMMATION, HIF, GENES
KG Connections21 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (3)

APOE-Dependent Autophagy Restoration
Score: 0.61
The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction
Score: 0.40
TFEB-PGC1α Mitochondrial-Lysosomal Decoupling
Score: 0.40

Related Analyses (4)

Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived
Gene expression changes in aging mouse brain predicting neur
neurodegeneration · archived
Metabolic reprogramming in neurodegenerative disease
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (12)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40
Neural Oscillation Dysfunction Validation in Parkinson's Dis
clinical · proposed · Score: 0.40

See Also (6)

HIF Signaling in Neurodegeneration
mechanism · KG edge: activates
MTOR Gene
gene · KG edge: activates
Genes
index · KG edge: activates
mTOR Signaling Dysregulation in Progressive Supranuclea
event · KG edge: activates
TFEB (Redirect)
redirect · KG edge: activates

Knowledge Graph (12 edges)

ANT2 activates MTOR
ANT2 activates TFEB
ANT2 implicated_in Tumorigenesis
ANT2 participates_in Blood Cell Development
ANT2 participates_in Gastrointestinal Motility
ANT2 participates_in Airway Hydration
ANT2 associated_with Nonalcoholic Fatty Liver Disease
ANT2 participates_in Myocardial Development
ANT2 regulates Glycolytic ATP Import
ANT2 activates INFLAMMATION