| Gene Symbol | NCSTN |
| Aliases | Nicastrin |
| Protein Family | Anterior pharynx defective (APH) family |
| Function | Nicastrin functions as part of the gamma-secretase complex which includes: - Presenilin (PSEN1 or PSEN2): The catalytic subunit - Aph-1 (APH1A/B/L): Stabilizes the complex - Pen-2: Required for comple |
| Subcellular Localization | Endoplasmic reticulum, Golgi, plasma membrane |
| Molecular Weight | 230 kDa |
| Amino Acids | 600 aa |
| Pathways | Notch, Notch signaling |
| UniProt ID | Q9Y5G0 |
| GeneCards | NCSTN |
| Human Protein Atlas | NCSTN |
| Substrate Recognition | NCSTN recognizes and binds to the extracellular domains of gamma-secretase substrates |
| Proteolytic Catalysis | Facilitates the intramembranous cleavage of APP, Notch, and other type I transmembrane proteins |
| Aβ Generation | NCSTN is essential for the gamma-secretase-mediated cleavage of APP to generate amyloid-beta peptides |
| [Neurons](/entities/neurons) | Throughout cortex, hippocampus, and cerebellum |
| Associated Diseases | AD, ALS, AMI, Alzheimer, Alzheimer's disease |
| Interactions | FAS, TNF, LMNA, APH1B, APOE, IL6 |
| KG Connections | 195 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |