gene 908 words KG: BAK1 2026-03-22
kind:genesection:genesstate:published
Contents

BAK1 Gene

🧬 Gene Info
Gene SymbolBAK1
Full NameBCL2-Antagonist/Killer 1
Chromosome6p21.31
Protein TypeBCL2 family (pro-apoptotic)
FunctionBAK1 is a 25 kDa protein localized primarily to the mitochondrial outer membrane
Molecular Weight25 kDa
PathwaysFerroptosis, Mtor, Necroptosis, Pyroptosis, apoptosis
UniProt IDQ9YM15
NCBI Gene ID578
Ensembl IDENSG00000130165
GeneCardsBAK1
Human Protein AtlasBAK1
Protein ClassBCL2 family (pro-apoptotic)
Associated DiseasesALS, OXIDATIVE_STRESS, Tumor, oxidative stress
InteractionsMTOR, BAX, BCL2, BECN1, BNIP3, BNIP3L
KG Connections148 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (8)

CYP46A1 Overexpression Gene Therapy
Score: 0.63
Senescent Microglia Resolution via Maresins-Senolytics Combi
Score: 0.55
Cryptic Exon Silencing Restoration
Score: 0.46
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45
Cross-Seeding Prevention Strategy
Score: 0.45

Related Analyses (4)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (9)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: biomarker_for
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: regulates
Packard Center for ALS Research
institution · KG edge: activates
Alzheimer Indonesia
institution · KG edge: regulates
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: regulates

Knowledge Graph (12 edges)

BAK1 biomarker_for BCL2L1
BAK1 associated_with BAX
BAK1 activates MTOR
BAK1 regulates FAS
BAK1 regulates MMP1
BAK1 associated_with BID
BAK1 causes BID
BAK1 causes MTOR
BAK1 regulates BCL2L1
BAK1 participates_in Mitochondria