gene 768 words KG: CASS4 2026-03-24
kind:genesection:genesstate:published
Contents

CASS4 — Cas Scaffold Protein Family Member 4

🧬 Gene Info
Gene SymbolCASS4
Full NameCas Scaffold Protein Family Member 4
Protein FamilyCAS family (CT10 Regulated Inositol Polyphosphate 4-phosphatase Type I)
Protein TypeScaffold Protein
FunctionCASS4 participates in cellular processes
Primary Expressionneurons and immune cells
Subcellular LocalizationCytoplasmic, associated with focal adhesions
Molecular Weight49 kDa
Amino Acids442 aa
PathwaysPI3K
UniProt IDQ9H6S3
GeneCardsCASS4
Human Protein AtlasCASS4
Cell Adhesion SignalingCASS4 localizes to focal adhesions and regulates integrin-mediated signaling pathways.
Tyrosine Kinase SignalingInteracts with Src family kinases and other signaling molecules.
Associated DiseasesALS, Alzheimer, Alzheimer's disease, Autoimmune, Cancer
InteractionsEPHA1, CLU, BIN1, CD33, CD2AP, APOE
KG Connections155 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (5)

Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.52
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
TREM2-mediated microglial tau clearance enhancement
Score: 0.49
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.42
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.41

Related Analyses (6)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (2)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Spinocerebellar Ataxia (SCA) Disease-Modifying Therapy Devel
validation · proposed · Score: 0.40

See Also (7)

Packard Center for ALS Research
institution · KG edge: activates
Alzheimer Indonesia
institution · KG edge: activates
APOE contributes to Alzheimer's disease by regulating b
hypothesis · KG edge: activates
CASS2 — CASP2 and RIPK1 Domain Containing Adaptor
gene · KG edge: interacts_with
BIN1 — Bridging Integrator 1
gene · KG edge: activates

Knowledge Graph (12 edges)

CASS4 associated_with CD33
CASS4 associated_with NME8
CASS4 associated_with BIN1
CASS4 associated_with CD2AP
CASS4 associated_with INPP5D
CASS4 associated_with EPHA1
CASS4 associated_with CLU
CASS4 associated_with CELF1
CASS4 associated_with MEF2C
CASS4 associated_with PTK2B