| Gene Symbol | PLD3 |
| Full Name | Phospholipase D3 |
| Chromosome | 19q13.32 |
| Protein Type | Enzyme |
| Function | is an endoplasmic reticulum-resident phospholipase enzyme that plays critical roles in cellular lipid metabolism and lysosomal function. |
| Primary Expression | brain regions vulnerable to neurodegeneration, and its expression is reduced in Alzheimer's disease brains |
| Amino Acids | 473 aa |
| Pathways | APP metabolism, Autophagy, Cholesterol, Mitophagy, nucleotide signaling |
| UniProt ID | Q8N8S7 |
| NCBI Gene ID | 23646 |
| Ensembl ID | ENSG00000119608 |
| OMIM | 614739 |
| GeneCards | PLD3 |
| Human Protein Atlas | PLD3 |
| p.Val255Met | One of the most studied risk variants |
| Associated Diseases | Alzheimer, Alzheimer's disease, Ms |
| Interactions | AKT3, AMYLOID, AND, APP, AUTOPHAGY, CGAS |
| SciDEX Hypotheses | Membrane Lipid Composition-Dependent Specificity S |
| KG Connections | 72 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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