protein 519 words KG: AIM2 2026-03-22
kind:proteinsection:proteinsstate:published
Contents

AIM2 Protein

🔬 Protein Info
Gene SymbolAIM2
Protein FamilyAIM2-like receptor (ALR)
FunctionAIM2 functions as a cytosolic DNA sensor forming the AIM2 inflammasome.
Subcellular LocalizationCytoplasm
Molecular Weight39 kDa
Amino Acids200 aa
PathwaysApoptosis, Autophagy, Cholesterol, Ferroptosis, Immune Response
UniProt IDQ9WZE6
GeneCardsAIM2
Human Protein AtlasAIM2
Associated DiseasesALS, Atherosclerosis, Cancer, Dementia, Infection
InteractionsZBP1, MLKL, TLR9, RIPK1, PYCARD, UBIQUITIN
KG Connections410 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (10)

Microglial AIM2 Inflammasome as the Primary Driver of TDP-43
Score: 0.60
Mitochondrial DAMPs-Driven AIM2 Inflammasome Activation in N
Score: 0.58
Calcium-Dysregulated mPTP Opening as an Alternative mtDNA Re
Score: 0.58
Mitochondrial DNA-Driven AIM2 Inflammasome Activation in Neu
Score: 0.58
Autophagosome Maturation Checkpoint Control
Score: 0.49

Related Analyses (8)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived

See Also (7)

Packard Center for ALS Research
institution · KG edge: activates
ATG16L1 - Autophagy Related 16 Like 1
gene · KG edge: activates
ATG14 Gene
gene · KG edge: activates
ASC (PYCARD)
gene · KG edge: activates
ACTB Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

AIM2 associated_with TNF
AIM2 associated_with MARCH7
AIM2 associated_with PYCARD
AIM2 associated_with LAMP1
AIM2 associated_with ASC
AIM2 associated_with ATG5
AIM2 associated_with CASP1
AIM2 associated_with IL1B
AIM2 associated_with NLRC4
AIM2 associated_with NLRP3