| Gene Symbol | NLRC4 |
| Protein Type | Receptor |
| Function | encodes a critical pattern recognition receptor that forms the NLRC4 inflammasome, a multiprotein complex essential for innate immunity and inflammatory responses. |
| Primary Expression | microglia - Minimal expression in astrocytes under normal conditions - Induction in infiltrating immune |
| Molecular Weight | 186 kDa |
| Pathways | NF-κB, MAPK pathway |
| Ensembl ID | ENSG00000102948 |
| GeneCards | NLRC4 |
| Human Protein Atlas | NLRC4 |
| Pattern recognition | LRR domain detects bacterial components |
| Oligomerization | Activated NLRC4 recruits ASC (PYCARD) via PYD interactions |
| Caspase-1 activation | NLRC4 CARD domain directly interacts with caspase-1 |
| Pyroptosis | Activated caspase-1 cleaves gasdermin D, causing pyroptotic cell death |
| Cytokine maturation | Caspase-1 processes pro-IL-1β and pro-IL-18 into active forms |
| Cross-talk with NLRP3 | potential co-activation in some contexts |
| Associated Diseases | ALS, Cancer, Cardiovascular, Infection, Inflammation, Ms |
| Interactions | AIM2, ALZHEIMER, AMPK, AMYLOID, AND, APOPTOSIS |
| KG Connections | 210 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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