gene

adam15

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about adam15: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

19Connections
0Hypotheses
0Analyses
16Outgoing
3Incoming

No summary available yet. View on Wiki →

🧬 Gene Info
Gene SymbolADAM15
Full NameADAM metallopeptidase domain 15
AliasesA Disintegrin and Metalloproteinase 15
Chromosome1q21.3
Functionis a member of the ADAM family of transmembrane metalloproteinases that plays important roles in cell adhesion, proteolysis, and signaling.
Primary Expressionvarious tissues including the brain, where it participates in neuronal function and neuroinflammation
Molecular Weight87.8 kDa
PathwaysNotch
UniProt IDQ13487
NCBI Gene ID8750
Ensembl IDENSG00000145040
OMIM605527
GeneCardsADAM15
Human Protein AtlasADAM15
Associated DiseasesAlzheimer's disease pathogenesis through multiple mechanism
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: adam15 — AlphaFold Q13487 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (5)

Knowledge base pages for this entity

ADAM15 Protein

protein · 2837 words

Genes Overview

gene · 905 words

ADAM15 Gene

gene · 795 words

Proteins

index · 296 words

Genes

index · 271 words

Pathway Diagram

flowchart TD
    N0["ADAM15"]
    N1["Cancer"]
    N0 -->|"activates"| N1
    N2["MMP9"]
    N0 -->|"activates"| N2
    N3["PI3K"]
    N0 -->|"activates"| N3
    N4["Nf-Kappab"]
    N0 -->|"activates"| N4
    N5["Pi3K/Akt"]
    N0 -->|"activates"| N5
    N6["Akt"]
    N0 -->|"activates"| N6
    N7["CKAP4"]
    N7 -->|"activates"| N0
    N8["RNA"]
    N8 -->|"activates"| N0
    N9["neurodegeneration"]
    N0 -->|"implicated in"| N9

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    classDef therapeutic fill:#1a2a2a,stroke:#26a69a,color:#e0e0e0
    class N1 disease
    class N2 gene
    class N3 gene
    class N4 pathway
    class N5 pathway
    class N6 protein
    class N7 gene
    class N8 gene

Outgoing (16)

TargetRelationTypeStr
Canceractivatesdisease0.65
MMP9activatesgene0.60
PI3Kactivatesgene0.60
CD33causesgene0.60
CD38causesgene0.60

Incoming (3)

SourceRelationTypeStr
CKAP4activatesgene0.60
RNAactivatesgene0.60
benchmark_ot_ad_answer_key:ADAM15data_indataset_row0.00

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found