Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about adam15: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | ADAM15 |
| Full Name | ADAM metallopeptidase domain 15 |
| Aliases | A Disintegrin and Metalloproteinase 15 |
| Chromosome | 1q21.3 |
| Function | is a member of the ADAM family of transmembrane metalloproteinases that plays important roles in cell adhesion, proteolysis, and signaling. |
| Primary Expression | various tissues including the brain, where it participates in neuronal function and neuroinflammation |
| Molecular Weight | 87.8 kDa |
| Pathways | Notch |
| UniProt ID | Q13487 |
| NCBI Gene ID | 8750 |
| Ensembl ID | ENSG00000145040 |
| OMIM | 605527 |
| GeneCards | ADAM15 |
| Human Protein Atlas | ADAM15 |
| Associated Diseases | Alzheimer's disease pathogenesis through multiple mechanism |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
flowchart TD
N0["ADAM15"]
N1["Cancer"]
N0 -->|"activates"| N1
N2["MMP9"]
N0 -->|"activates"| N2
N3["PI3K"]
N0 -->|"activates"| N3
N4["Nf-Kappab"]
N0 -->|"activates"| N4
N5["Pi3K/Akt"]
N0 -->|"activates"| N5
N6["Akt"]
N0 -->|"activates"| N6
N7["CKAP4"]
N7 -->|"activates"| N0
N8["RNA"]
N8 -->|"activates"| N0
N9["neurodegeneration"]
N0 -->|"implicated in"| N9
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
classDef therapeutic fill:#1a2a2a,stroke:#26a69a,color:#e0e0e0
class N1 disease
class N2 gene
class N3 gene
class N4 pathway
class N5 pathway
class N6 protein
class N7 gene
class N8 gene| Target | Relation | Type | Str |
|---|---|---|---|
| Cancer | activates | disease | 0.65 |
| MMP9 | activates | gene | 0.60 |
| PI3K | activates | gene | 0.60 |
| CD33 | causes | gene | 0.60 |
| CD38 | causes | gene | 0.60 |
| GPNMB | causes | gene | 0.60 |
| GRN | causes | gene | 0.60 |
| SIGLEC9 | causes | gene | 0.60 |
| Nf-Κb | activates | pathway | 0.60 |
| Pi3K/Akt | activates | pathway | 0.60 |
| Akt | activates | protein | 0.60 |
| Alzheimer's disease | causes | disease | 0.60 |
| Parkinson's disease | causes | disease | 0.60 |
| ALS | causes | disease | 0.60 |
| oxidative stress response | participates_in | pathway | 0.60 |
| benchmark_ot_ad_answer_key:ADAM15 | data_in | dataset_row | 0.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| CKAP4 | activates | gene | 0.60 |
| RNA | activates | gene | 0.60 |
| benchmark_ot_ad_answer_key:ADAM15 | data_in | dataset_row | 0.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||