gene 1,033 words KG: FAM134B 2026-03-27
kind:genesection:genesstate:publishedtopic:parkinsonstopic:neuropathy
Contents

FAM134B — Family With Sequence Similarity 134 Member B

🧬 Gene Info
Gene SymbolFAM134B
Full NameFamily With Sequence Similarity 134 Member B
Chromosome5p15.1
Protein TypeReceptor
Functionis a critical ER-phagy receptor protein that plays an essential role in endoplasmic reticulum quality control and turnover.
Primary ExpressionNeurons, peripheral sensory neurons
Amino Acids476 aa
PathwaysAutophagy, Innate Immunity
UniProt IDQ9H6Y3
NCBI Gene ID54494
Ensembl IDENSG00000144136
OMIM613374
GeneCardsFAM134B
Human Protein AtlasFAM134B
AliasRETREG1, Retregulin
Associated DiseasesAD, ALI, ALS, Alzheimer, Neuropathy
InteractionsLC3, EPAS1, MIRO1, CTSD, RB1, EIF2AK3
KG Connections487 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (7)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.36
APOE-Dependent Autophagy Restoration
Score: 0.61
Dual-Domain Antibodies with Engineered Fc-FcRn Affinity Modu
Score: 0.57
Phase-Separated Organelle Targeting
Score: 0.52
Stress Granule Phase Separation Modulators
Score: 0.49

Related Analyses (6)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived
Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (10)

Actin Cytoskeleton Dynamics in Neurodegeneration
mechanism · KG edge: co_discussed
Packard Center for ALS Research
institution · KG edge: activates
Accelerating Medicines Partnership for Alzheimer's Dise
institution · KG edge: implicated_in
Alzheimer Indonesia
institution · KG edge: interacts_with
ATM Gene
gene · KG edge: interacts_with

Knowledge Graph (12 edges)

FAM134B interacts_with LC3
FAM134B interacts_with EPAS1
FAM134B interacts_with MIRO1
FAM134B interacts_with CTSD
FAM134B interacts_with RB1
FAM134B interacts_with EIF2AK3
FAM134B interacts_with PRKN
FAM134B interacts_with BCL2L11
FAM134B interacts_with MUL1
FAM134B interacts_with BNIP3