gene 1,513 words KG: ISG15
Contents

ISG15 — Interferon-Stimulated Gene 15

🧬 Gene Info
Gene SymbolISG15
Full NameInterferon-Stimulated Gene 15
Chromosome1p36.33
Functionis a ubiquitin-like protein that is induced by type I interferons (IFN-α/β) and plays a critical role in the innate immune response.
Amino Acids165 aa
Exons2
PathwaysAkt, Autophagy, Lipid Metabolism, Mapk, Pi3K
UniProt ID[P51959](https://www.uniprot.org/uniprot/P51959)
Ensembl IDENSG00000187608
OMIM607117
GeneCardsISG15
Human Protein AtlasISG15
Associated DiseasesAls, Alzheimer Disease, Cancer, Cognitive Deficits, Depression, Inflammation
InteractionsAKT, ALZHEIMER, ALZHEIMER DISEASE, AND, ASC, ASK1
KG Connections279 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (13)

CYP46A1 Overexpression Gene Therapy
Score: 0.86
Transcriptional Autophagy-Lysosome Coupling
Score: 0.84
SASP-Driven Aquaporin-4 Dysregulation
Score: 0.78
Glymphatic System-Enhanced Antibody Clearance Reversal
Score: 0.76
HSP90-Tau Disaggregation Complex Enhancement
Score: 0.75

Related Analyses (5)

Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (14)

Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: activates
A2M Gene
gene · KG edge: associated_with
ACTB Gene
gene · KG edge: associated_with
AQP4 (Aquaporin-4 Gene)
gene · KG edge: associated_with
AURKA Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

ISG15 participates_in INTERFERON_RESPONSE
CSF2 regulates ISG15
NAMPT regulates ISG15
FGF2 regulates ISG15
CXCL10 activates ISG15
HSPA1A regulates ISG15
FGF8 regulates ISG15
TLR4 regulates ISG15
ISG15 activates STAT1
ISG15 regulates CSF2RA

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