gene 2,018 words KG: CST3
Contents

CST3 Gene - Cystatin C

🧬 Gene Info
Gene SymbolCST3
Full NameCystatin C
Chromosome20p11.21
FunctionCysteine protease inhibition
Molecular Weight13 kDa
Amino Acids120 aa
UniProt IDP01034
NCBI Gene ID1471
Ensembl IDENSG00000141540
OMIM123400
GeneCardsCST3
Human Protein AtlasCST3
Protein Size120 amino acids (~13 kDa)
BiomarkerStrengths
Aβ42Direct disease relevance
Associated DiseasesALS, Diabetes, Hypertension
InteractionsCTSS, NPTX1, SERPINA3, NRXN2, VGF, CTSB
KG Connections42 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (4)

Complement C1q Mimetic Decoy Therapy
Score: 0.48
Complement C1q Subtype Switching
Score: 0.44
Complement C1QA Spatial Gradient in Cortical Layers
Score: 0.43
Complement-Mediated Synaptic Pruning Dysregulation
Score: 0.40

Related Analyses (5)

4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Gene expression changes in aging mouse brain predicting neur
neurodegeneration · archived
SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (5)

s:** - Compare brain penetration in FcRn+/+ vs FcRn-/- mice
falsification · proposed · Score: 0.40
Proposed experiment from debate on Synaptic pruning by micro
falsification · proposed · Score: 0.40
Experiment: Autoimmune Hypothesis Testing in AD
clinical · proposed · Score: 0.40
Experimental: CAAR-T Cell Therapy for Autoantibody-Mediated
clinical · proposed · Score: 0.40
cGAS-STING Pathway Validation Study in Parkinson's Disease
clinical · proposed · Score: 0.40

See Also (10)

Packard Center for ALS Research
institution · KG edge: activates
Alzheimer Indonesia
institution · KG edge: regulates
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: regulates
CTSS — Cathepsin S
gene · KG edge: activates
CTSD — Cathepsin D
gene · KG edge: activates

Knowledge Graph (12 edges)

CST3 regulates APBB1
CST3 regulates C1QA
CST3 activates CTSS
CST3 inhibits NPTX1
CST3 inhibits SERPINA3
CST3 inhibits NRXN2
CST3 inhibits VGF
CST3 activates CTSB
CST3 activates CTSD
CST3 regulates APP