gene 536 words KG: NRXN2 2026-03-24
kind:genesection:genesstate:published
Contents

NRXN2 Gene

🧬 Gene Info
Gene SymbolNRXN2
Full NameNeurexin 2
Chromosome11q13.2
Functionencodes a presynaptic cell adhesion molecule essential for synaptic transmission.
Molecular Weight180 kDa
UniProt IDQ9UHG0
NCBI Gene ID9379
Ensembl IDEnsembl
GeneCardsNRXN2
Human Protein AtlasNRXN2
DiseaseMechanism
Autism Spectrum DisorderMutations affect synaptic connectivity
SchizophreniaAltered expression in brains
Alzheimer's DiseaseRole in synaptic dysfunction
ApproachStatus
Associated DiseasesALS, Alzheimer
InteractionsNPTX2, NLGN1, CTSB, CTSD, NRXN3, NRXN1
KG Connections44 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (3)

Trans-Synaptic Adhesion Molecule Modulation
Score: 0.34
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45

Related Analyses (4)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (14)

Packard Center for ALS Research
institution · KG edge: regulates
Dementia Australia
institution · KG edge: inhibits
Alzheimer Indonesia
institution · KG edge: inhibits
NRXN1 Gene
gene · KG edge: interacts_with
NPTX2 — Neuronal Pentraxin 2
gene · KG edge: interacts_with

Knowledge Graph (12 edges)

NRXN2 interacts_with NPTX2
NRXN2 interacts_with NLGN1
NRXN2 regulates NLGN1
NRXN2 regulates VGF
NRXN2 inhibits CTSB
NRXN2 inhibits CTSD
NRXN2 regulates NRXN3
NRXN2 regulates NRXN1
NRXN2 interacts_with NRXN3
NRXN2 interacts_with NRXN1