NPTX1

Understanding Entity Pages

This page aggregates everything SciDEX knows about NPTX1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

NPTX1 (Neuronal Pentraxin 1) - synaptic plasticity, complement-mediated synapse elimination, neuronal excitability, implicated in Alzheimer's disease and epilepsy

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graph TD
    NPTX1["<b>NPTX1</b>"]
    Neurodegeneration{"Neurodegeneration"}
    NPTX1 -->|"biomarker for"| Neurodegeneration
    Als{"Als"}
    NPTX1 -->|"biomarker for"| Als
    Inflammation{"Inflammation"}
    NPTX1 -->|"associated with"| Inflammation
    Neuroinflammation{"Neuroinflammation"}
    NPTX1 -->|"associated with"| Neuroinflammation
    Alzheimer{"Alzheimer"}
    NPTX1 -->|"biomarker for"| Alzheimer
    ALS{"ALS"}
    NPTX1 -->|"biomarker for"| ALS
    CHIT1["CHIT1"]
    NPTX1 -->|"associated with"| CHIT1
    MDH1["MDH1"]
    NPTX1 -->|"biomarker for"| MDH1
    PDGFRB["PDGFRB"]
    NPTX1 -->|"associated with"| PDGFRB
    SQSTM1["SQSTM1"]
    NPTX1 -->|"biomarker for"| SQSTM1
    BDNF["BDNF"]
    NPTX1 -->|"biomarker for"| BDNF
    APOE["APOE"]
    NPTX1 -->|"biomarker for"| APOE
    IL9["IL9"]
    IL9 -->|"biomarker for"| NPTX1
    VEGFA["VEGFA"]
    VEGFA -->|"associated with"| NPTX1
    IL4["IL4"]
    IL4 -->|"biomarker for"| NPTX1
    FGF2["FGF2"]
    FGF2 -->|"biomarker for"| NPTX1
    GFAP["GFAP"]
    GFAP -->|"biomarker for"| NPTX1
    SQSTM1 -->|"biomarker for"| NPTX1
    CHIT1 -->|"associated with"| NPTX1
    NEFL["NEFL"]
    NEFL -->|"biomarker for"| NPTX1
    CHI3L1["CHI3L1"]
    CHI3L1 -->|"associated with"| NPTX1
    MDH1 -->|"biomarker for"| NPTX1
    BDNF -->|"biomarker for"| NPTX1
    PDGFRB -->|"associated with"| NPTX1
    style NPTX1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0