| Gene Symbol | CX3CR1 |
| Full Name | CX3C Chemokine Receptor 1 |
| Chromosome | 3p21.31 |
| Protein Type | Gpcr |
| Target Class | Gpcr |
| Function | GPCR antagonist modulating microglial activation and neuroinflammation |
| Mechanism of Action | GPCR antagonist modulating microglial activation and neuroinflammation |
| Primary Expression | Microglia, Monocytes, NK cells, T cells |
| Druggability | Low (0.44) |
| Clinical Stage | Phase II |
| Pathways | Complement, Immune Response, Neuroinflammatory, Oxidative Stress, Synaptic Plasticity |
| UniProt ID | P41597 |
| NCBI Gene ID | 1524 |
| Ensembl ID | ENSG00000168329 |
| OMIM | 601470 |
| GeneCards | CX3CR1 |
| Human Protein Atlas | CX3CR1 |
| Associated Diseases | ALS, Aging, Alzheimer, Alzheimer's Disease |
| Known Drugs/Compounds | Baicalein |
| Interactions | TREM2, APP, TNF, CD163, CD68, NRF2 |
| SciDEX Target | View Target Profile (7 clinical trials) |
| SciDEX Hypotheses | Fractalkine Axis Amplification via CX3CR1 Positive Optogenetic Microglial Deactivation via Engineered |
| KG Connections | 1272 knowledge graph edges |
| Databases | GeneCardsHPASTRING |