gene 748 words KG: APOA1 2026-03-22
kind:genesection:genesstate:published
Contents

APOA1 Gene

🧬 Gene Info
Gene SymbolAPOA1
Full NameApolipoprotein A1
ChromosomeChr11q23.3
FunctionThe APOA1 gene encodes Apolipoprotein A1, the primary protein component of high-density lipoprotein (HDL) particles.
UniProt IDP02647
NCBI Gene ID335
Ensembl IDENSG00000118137
OMIM107680
GeneCardsAPOA1
Human Protein AtlasAPOA1
Associated DiseasesAD, ALS, AMI, ARM, Alzheimer
InteractionsULK1, ATG5, EIF4EBP1, LC3, MTOR, ABCG1
KG Connections297 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (27)

Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.51
APOE4-Selective Lipid Nanoemulsion Therapy
Score: 0.49
APOE Isoform Conversion Therapy
Score: 0.44
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.62

Related Analyses (4)

Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (15)

Actin Cytoskeleton Dynamics in Neurodegeneration
mechanism · KG edge: co_discussed
Packard Center for ALS Research
institution · KG edge: activates
Accelerating Medicines Partnership for Alzheimer's Dise
institution · KG edge: implicated_in
Alzheimer Indonesia
institution · KG edge: degrades
ACTB Gene
gene · KG edge: interacts_with

Knowledge Graph (12 edges)

APOA1 activates ATG5
APOA1 activates EIF4EBP1
APOA1 activates LC3
APOA1 activates LOX
APOA1 activates P2RY12
APOA1 activates P62
APOA1 activates SQSTM1
APOA1 activates ULK1
APOA1 regulates CD36
APOA1 regulates DGAT1