gene 748 words KG: ent-gene-f6dfa559
Contents

APOA1 Gene

🧬 Gene Info
Gene SymbolAPOA1
Full NameApolipoprotein A1
ChromosomeChr11q23.3
FunctionThe APOA1 gene encodes Apolipoprotein A1, the primary protein component of high-density lipoprotein (HDL) particles.
UniProt IDP02647
NCBI Gene ID335
Ensembl IDENSG00000118137
OMIM107680
GeneCardsAPOA1
Human Protein AtlasAPOA1
Associated DiseasesAD, Als, Alzheimer, AMI, ARM
Interactions4E-BP1, ABCA1, abca2, ABCA2, ABCG1, ACTB
KG Connections291 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (27)

APOE4-Selective Lipid Nanoemulsion Therapy
Score: 0.74
APOE Isoform Conversion Therapy
Score: 0.72
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72
APOE-Dependent Autophagy Restoration
Score: 0.89
Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.88
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
CYP46A1 Overexpression Gene Therapy
Score: 0.77
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Circadian Clock-Autophagy Synchronization
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
Circadian-Synchronized Proteostasis Enhancement
Score: 0.74
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
Circadian Rhythm Entrainment of Reactive Astrocytes
Score: 0.72
Purinergic Signaling Polarization Control
Score: 0.71
Circadian Glymphatic Rescue Therapy (Melatonin-focused)
Score: 0.71
Metabolic Circuit Breaker via Lipid Droplet Modulation
Score: 0.71
Membrane Cholesterol Gradient Modulators
Score: 0.71
Purinergic P2Y12 Inverse Agonist Therapy
Score: 0.70
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Related Analyses (4)

Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (15)

Actin Cytoskeleton Dynamics in Neurodegeneration
mechanism · KG edge: co_discussed
ABCA2 Gene - ATP Binding Cassette Subfamily A Member 2
gene · KG edge: activates
ABCG1 Gene
gene · KG edge: interacts_with
ACTB Gene
gene · KG edge: interacts_with
Alzheimer Indonesia
institution · KG edge: degrades

Knowledge Graph (2 edges)

ent-gene-f6dfa559 data_in benchmark_ot_ad_answer_key:APOA1
benchmark_ot_ad_answer_key:APOA1 data_in ent-gene-f6dfa559

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