concept

ATGL

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ATGL: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

55Connections

0Hypotheses

0Analyses

39Outgoing

16Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	ATGL
Key Genes/Proteins	Rab8a-PLIN5 complex, KDM6B, ULK1, PPAR, MTNR1A, CYTOKINES
Related Diseases	ALS, Als, Neuroinflammation, Inflammation
Related Pathways	Autophagy, Epigenetic

Wiki Pages (7)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    ATGL["ATGL"]
    ATGL -->|"mediates"| Lipid_Mobilization["Lipid Mobilization"]
    ATGL -->|"activates"| ALS["ALS"]
    ATGL -->|"activates"| Als["Als"]
    ATGL -->|"activates"| Neuroinflammation["Neuroinflammation"]
    ATGL -->|"activates"| Inflammation["Inflammation"]
    ATGL -->|"activates"| KDM6B["KDM6B"]
    ATGL -->|"activates"| ULK1["ULK1"]
    ATGL -->|"activates"| Autophagy["Autophagy"]
    JMJD3["JMJD3"] -->|"upregulates"| ATGL
    Rab8a_PLIN5_complex["Rab8a-PLIN5 complex"] -->|"recruits"| ATGL
    GENES["GENES"] -->|"activates"| ATGL
    LC3["LC3"] -->|"activates"| ATGL
    AUTOPHAGY["AUTOPHAGY"] -->|"activates"| ATGL
    TFEB["TFEB"] -->|"activates"| ATGL
    FGF21["FGF21"] -->|"activates"| ATGL
    AND["AND"] -->|"activates"| ATGL

Outgoing (39)

Target	Relation	Type	Str
lipolysis	promotes	process	0.85
ALS	activates	disease	0.65
Als	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Inflammation	activates	disease	0.65
KDM6B	activates	gene	0.60
ULK1	activates	gene	0.60
Autophagy	activates	pathway	0.60
Epigenetic	activates	pathway	0.60
PPAR	activates	gene	0.60
Fibroblast	activates	cell_type	0.60
MTNR1A	activates	gene	0.60
CYTOKINES	activates	gene	0.60
Microglia	activates	cell_type	0.60
Neuron	activates	cell_type	0.60
MICROGLIA	activates	gene	0.60
FGF21	activates	gene	0.60
LC3	activates	gene	0.60
AND	activates	gene	0.60
GENES	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
ATG7	activates	gene	0.60
Cytokine	activates	protein	0.60
Fgf	activates	protein	0.60
neuroinflammation	activates	disease	0.60
microglia	expressed_in	cell_type	0.60
LIPA	activates	gene	0.60
MAP1LC3	activates	gene	0.60
PLIN2	activates	gene	0.60
autophagy pathway	participates_in	pathway	0.60
ATP	activates	gene	0.60
Fibroblast	expressed_in	cell_type	0.55
Neuron	expressed_in	cell_type	0.55
Microglia	expressed_in	cell_type	0.55
PLIN2	inhibits	gene	0.55
DGAT1	interacts_with	gene	0.55
PLIN3	interacts_with	gene	0.55
SOAT1	interacts_with	gene	0.55
astrocytes	expressed_in	cell_type	0.55

Incoming (16)

Source	Relation	Type	Str
Rab8a-PLIN5 complex	recruits	protein	0.85
GENES	activates	gene	0.60
LC3	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
TFEB	activates	gene	0.60
FGF21	activates	gene	0.60
AND	activates	gene	0.60
ATG7	activates	gene	0.60
ULK1	activates	gene	0.60
MICROGLIA	activates	gene	0.60
INFLAMMATION	activates	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
MTNR1A	activates	gene	0.60
CYTOKINES	activates	gene	0.60
PPAR	activates	gene	0.60
ATG	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

ATGL

Understanding Entity Pages

Wiki Pages (7)

PLIN1 — Perilipin 1

PLIN5 — Perilipin 5

PLIN2 Gene

plin3

CIDEB — Cell Death-Inducing DFFA-Like Effector B