gene 977 words KG: DLK1 2026-03-27
kind:genesection:genesstate:publishednotchcell-fateimprintedneurodevelopmentadamts
Contents

DLK1 Gene

🧬 Gene Info
Gene SymbolDLK1
Full NameDelta Like Non-Canonical Notch Ligand 1
AliasesDelta-Like 1 Homolog
Chromosome14q32.12
Functionis a member of the epidermal growth factor (EGF)-like family that functions as a non-canonical Notch ligand and regulator of cell fate decisions.
Amino Acids396 aa
Exons8
PathwaysNotch
UniProt ID[O00548](https://www.uniprot.org/uniprot/O00548)
Ensembl IDENSG00000176358
OMIM176290
GeneCardsDLK1
Human Protein AtlasDLK1
N-terminal signal peptideDirects secretion
Multiple EGF-like repeatsSix EGF-like domains in the extracellular region
Associated DiseasesALS, ICPP, Idiopathic Central Precocious Puberty, Ms
InteractionsGABRA1, ATG16L1, ATG5, LC3, GAIN, FERROPTOSIS
KG Connections64 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (4)

CYP46A1 Overexpression Gene Therapy
Score: 0.63
AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.57
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45
Biorhythmic Interference via Controlled Sleep Oscillations
Score: 0.41

Related Analyses (4)

Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (12)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: activates
Packard Center for ALS Research
institution · KG edge: associated_with
GAIN Gene - GABA-A Receptor Associated Protein Like 2
gene · KG edge: associated_with
GABRA1 Gene
gene · KG edge: associated_with
ATG5 — Autophagy Related 5
gene · KG edge: inhibits

Knowledge Graph (12 edges)

DLK1 associated_with GABRA1
DLK1 interacts_with GABRA1
DLK1 inhibits ATG16L1
DLK1 inhibits ATG5
DLK1 activates LC3
DLK1 associated_with GAIN
DLK1 associated_with Idiopathic Central Precocious Puberty
DLK1 risk_factor_for Idiopathic Central Precocious Puberty
DLK1 interacts_with GAIN
DLK1 risk_factor_for Central Precocious Puberty