gene 584 words KG: DRAM1 2026-03-22
kind:genesection:genesstate:published
Contents

DRAM1 Gene

🧬 Gene Info
Gene SymbolDRAM1
Full NameDNA Damage Regulated Autophagy Modulator 1
Chromosome7q34
FunctionDRAM1 is a lysosomal membrane protein that acts as a key regulator of autophagy, a cellular process critical for clearing misfolded proteins and damaged organelles.
Molecular Weight37 kDa
PathwaysmTOR, mtor
UniProt IDQ8WXX5
NCBI Gene ID55332
Ensembl IDENSG00000138271
OMIM610686
GeneCardsDRAM1
Human Protein AtlasDRAM1
ApproachStatus
Autophagy enhancersResearch
[mTOR](/entities/mtor) inhibitorsApproved
Associated DiseasesLupus
InteractionsVAMP8, SNAP29, STIM1, ULK1, AUTOPHAGY, STX17
KG Connections39 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (5)

CYP46A1 Overexpression Gene Therapy
Score: 0.63
APOE-Dependent Autophagy Restoration
Score: 0.61
Autophagosome Maturation Checkpoint Control
Score: 0.49
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45
Lysosomal Positioning Dynamics Modulation
Score: 0.43

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (15)

Ubiquitin
protein · KG edge: regulates
Adaptive Immunity in Neurodegeneration
mechanism · KG edge: associated_with
VAMP8 — Vesicle Associated Membrane Protein 8
gene · KG edge: activates
STX17 Gene
gene · KG edge: activates
STUB1 — CHIP
gene · KG edge: regulates

Knowledge Graph (12 edges)

DRAM1 regulates STUB1
DRAM1 activates VAMP8
DRAM1 activates SNAP29
DRAM1 interacts_with STIM1
DRAM1 activates STIM1
DRAM1 activates ULK1
DRAM1 activates Carcinoma
DRAM1 activates Ms
DRAM1 interacts_with Autophagy
DRAM1 interacts_with AUTOPHAGY