protein 1,146 words KG: STUB1 2026-03-29
kind:proteinsection:proteinsstate:published
Contents

STUB1/CHIP Protein

🔬 Protein Info
Gene SymbolSTUB1
Full NameSTIP1 Homology And U-Box Containing Protein 1
AliasesCHIP
Chromosome16p13.3
Protein FamilyU-box E3 ubiquitin ligase family
Functionencodes a ubiquitin ligase and cochaperone that plays critical roles in protein quality control
Subcellular LocalizationCytoplasm, Nucleus
Molecular Weight34.6 kDa
Amino Acids305 aa
PathwaysChaperone, Proteasome, Ubiquitin-Proteasome
UniProt IDQ9UNE7
NCBI Gene ID10273
Ensembl IDENSG00000120539
OMIM607207
GeneCardsSTUB1
Human Protein AtlasSTUB1
Associated DiseasesAls, Amyotrophic Lateral Sclerosis, Ataxia, Huntington, Ms, Neuroblastoma
Known Drugs/Compoundsrapamycin
InteractionsATG10, CALCINEURIN, ATG12, BAG3, HSPB8, SNAP29
KG Connections242 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (15)

Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Proteostasis Enhancement via APOE Chaperone Targeting
Score: 0.50
Autophagosome Maturation Checkpoint Control
Score: 0.49
Lysosomal Calcium Channel Modulation Therapy
Score: 0.49
Perforant Path Presynaptic Terminal Protection Strategy
Score: 0.48

Related Analyses (10)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived

See Also (10)

Packard Center for ALS Research
institution · KG edge: activates
BECN1 Gene
gene · KG edge: activates
BCL2 Gene
gene · KG edge: activates
BAG3 Gene
gene · KG edge: activates
ATM Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

STUB1 associated_with PPARGC1A
STUB1 associated_with TARDBP
STUB1 associated_with TREH
STUB1 associated_with BECN1
STUB1 associated_with GAPDH
STUB1 associated_with PPP3CB
STUB1 associated_with HSPB8
STUB1 associated_with MAP1LC3B
STUB1 associated_with MTOR
STUB1 associated_with BAG3