gene 2,756 words KG: ESRRB 2026-03-28
kind:genesection:genesstate:published
Contents

ESRRB Gene

🧬 Gene Info
Gene SymbolESRRB
AliasesEstrogen-Related Receptor Beta
Chromosome14q24.3
Protein TypeReceptor
Functionis an orphan nuclear receptor that belongs to the estrogen-related receptor (ERR) subfamily of nuclear receptors.
Primary Expressionvarious peripheral tissues [6](https://pubmed
Amino Acids503 aa
PathwaysStem Cell
Ensembl IDENSG00000119715
GeneCardsESRRB
Human Protein AtlasESRRB
gene = ESRRBname = Estrogen-Related Receptor Beta
ncbi_gene_id = 2099ensembl = ENSG00000119715
PGC-1αCoactivation
NRF-1Synergistic regulation
Associated Diseasesneurodegeneration
InteractionsCDKN1A, MYC, CANCER, SMAD7, SMAD2
KG Connections11 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (9)

Digital Twin-Guided Metabolic Reprogramming
Score: 0.61
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.62
AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.57

Related Analyses (4)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (7)

Packard Center for ALS Research
institution · KG edge: contributes_to
SMAD7 Gene
gene · KG edge: activates
SMAD2 Gene
gene · KG edge: inhibits
MYC Gene
gene · KG edge: activates
CDKN1A — Cyclin-Dependent Kinase Inhibitor 1A
gene · KG edge: inhibits

Knowledge Graph (11 edges)

ESRRB inhibits CDKN1A
ESRRB activates MYC
ESRRB activates CANCER
ESRRB activates Tumor
ESRRB contributes_to Prostate Cancer
ESRRB activates Cancer
ESRRB contributes_to Als
ESRRB contributes_to Breast Cancer
ESRRB regulates Stem Cell
SMAD7 activates ESRRB