gene 2,035 words KG: SMAD7 2026-03-27
kind:genesection:genesstate:published
Contents

SMAD7 Gene

🧬 Gene Info
Gene SymbolSMAD7
Full NameSMAD Family Member 7
Chromosome18q21.1
Functionis a critical inhibitory SMAD protein that negatively regulates transforming growth factor-beta (TGF-β) and bone morphogenetic protein (BMP) signaling pathways.
Amino Acids426 aa
Exons6
PathwaysTGF-β, TGF-β signaling
UniProt IDO15117
NCBI Gene ID4093
Ensembl IDENSG00000101680
OMIM602932
GeneCardsSMAD7
Human Protein AtlasSMAD7
Associated Diseasespostoperative cognitive dysfunction
InteractionsMLCK, SMAD2, GBM, JUN, ESRRB, CDKN1A
KG Connections64 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (3)

CYP46A1 Overexpression Gene Therapy
Score: 0.63
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.48
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (14)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: therapeutic_target
Packard Center for ALS Research
institution · KG edge: activates
SMAD3 — SMAD Family Member 3
gene · KG edge: regulates
SMAD2 Gene
gene · KG edge: regulates
RB1CC1 Gene
gene · KG edge: regulates

Knowledge Graph (12 edges)

SMAD7 regulates UBIQUITIN
SMAD7 regulates RB1CC1
SMAD7 inhibits MLCK
SMAD7 expressed_in TNF
SMAD7 inhibits SMAD2
SMAD7 inhibits GBM
SMAD7 inhibits JUN
SMAD7 activates ESRRB
SMAD7 inhibits CDKN1A
SMAD7 activates MYC