gene 2,115 words KG: FANCA 2026-03-28
kind:genesection:genesstate:published
Contents

FANCA Gene

🧬 Gene Info
Gene SymbolFANCA
Full NameFanconi Anemia Group A
Chromosome16q24.3
Molecular Weight180 kDa
Amino Acids1635 aa
Exons43
UniProt ID[O15360](https://www.uniprot.org/uniprot/O15360)
Ensembl IDENSG00000188191
OMIM607139
GeneCardsFANCA
Human Protein AtlasFANCA
Bone marrowHighest expression, consistent with the essential role in hematopoiesis
TestisHigh expression, reflecting ongoing spermatogenesis
Associated DiseasesFanconi Anemia
InteractionsTUFM, FANCE, ATR, DNA, FANCI, P53
KG Connections33 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (7)

CYP46A1 Overexpression Gene Therapy
Score: 0.63
APOE-Dependent Autophagy Restoration
Score: 0.61
PARP1 Inhibition Therapy
Score: 0.58
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.48
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45

Related Analyses (5)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
CRISPR-based therapeutic approaches for neurodegenerative di
neurodegeneration · archived

See Also (9)

ER Stress and Unfolded Protein Response in Corticobasal
mechanism · KG edge: contributes_to
Packard Center for ALS Research
institution · KG edge: contributes_to
AIM2 Inflammasome Modulation Therapy for Neurodegenerat
idea · KG edge: contributes_to
TUFM Gene
gene · KG edge: interacts_with
fance
gene · KG edge: interacts_with

Knowledge Graph (12 edges)

FANCA interacts_with TUFM
FANCA interacts_with FANCE
FANCA contributes_to AIM2
FANCA interacts_with ATR
FANCA causes Fanconi Anemia
FANCA interacts_with Als
FANCA interacts_with Cancer
FANCA interacts_with Tumor
FANCA interacts_with Mitochondrial Function
FANCA interacts_with DNA