gene 2,477 words KG: FANCC 2026-03-08
kind:genesection:genestopic:alzheimerstopic:parkinsonsstate:published
Contents

FANCC Gene

🧬 Gene Info
Gene SymbolFANCC
Full NameFanconi Anemia Group C Protein
Chromosome9q22.33
Protein FamilyFanconi anemia complementation group
Functionis a core component of the Fanconi anemia (FA) DNA repair pathway, a crucial mechanism for maintaining genomic stability through the repair of DNA interstrand crosslinks (ICLs) [1][2].
Primary ExpressionUbiquitous, high in bone marrow
Molecular Weight~64 kDa
Amino Acids558 aa
Pathwayspathway: [@pathway]
UniProt IDQ00597
NCBI Gene ID2176
Ensembl IDENSG00000144567
OMIM603234
GeneCardsFANCC
Human Protein AtlasFANCC
Associated DiseasesAlzheimer's disease, Parkinson's disease
InteractionsATM, FANCA, FANCE, ATR, DNA, FANCI
KG Connections26 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (9)

Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
CYP46A1 Overexpression Gene Therapy
Score: 0.63
APOE-Dependent Autophagy Restoration
Score: 0.61
PARP1 Inhibition Therapy
Score: 0.58
AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.57

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (12)

ER Stress and Unfolded Protein Response in Corticobasal
mechanism · KG edge: contributes_to
Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: contributes_to
Packard Center for ALS Research
institution · KG edge: contributes_to
AIM2 Inflammasome Modulation Therapy for Neurodegenerat
idea · KG edge: contributes_to
fance
gene · KG edge: interacts_with

Knowledge Graph (12 edges)

FANCC interacts_with ATM
FANCC interacts_with FANCA
FANCC interacts_with FANCE
FANCC contributes_to AIM2
FANCC interacts_with ATR
FANCC contributes_to APOPTOSIS
FANCC interacts_with DNA
FANCC contributes_to CGAS-STING
FANCC interacts_with FANCI
FANCC interacts_with P53