gene 2,416 words KG: FANCE
Contents

FANCE Gene

🧬 Gene Info
Gene SymbolFANCE
Chromosome6p21.31
Protein TypeAdaptor Protein
Functionencodes an essential adaptor protein that plays a critical role in the Fanconi anemia (FA) DNA repair pathway.
Molecular Weight44 kDa
Amino Acids396 aa
Ensembl IDENSG00000112039
GeneCardsFANCE
Human Protein AtlasFANCE
Human-Mouse85% identical at the amino acid level
Human-Zebrafish72% identical
DrosophilaPartial ortholog with 45% identity
YeastNo clear ortholog (FA pathway is metazoan-specific)
Associated Diseasesneurodegeneration
InteractionsATM, ATR, DNA, FANCA, FANCC, FANCI
KG Connections24 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (2)

PARP1 Inhibition Therapy
Score: 0.74
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75

Related Analyses (1)

Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (5)

cGAS-STING Pathway Validation Study in Parkinson's Disease
clinical · proposed · Score: 0.40
CRISPR Gene Correction Approaches for CBS/PSP
clinical · proposed · Score: 0.40
Epigenetic Dysregulation Validation in Parkinson's Disease
clinical · proposed · Score: 0.40
Non-Motor Symptom Progression in Parkinson's Disease — Mecha
clinical · proposed · Score: 0.40
Spinocerebellar Ataxia (SCA) Disease-Modifying Therapy Devel
validation · proposed · Score: 0.40

See Also (12)

NeuRon Therapeutics
company · KG edge: contributes_to
Neurodegeneration
disease · KG edge: implicated_in
Apoptosis in Neurodegeneration
entity · KG edge: contributes_to
DNA Damage Repair Deficiency Validation Study in Parkin
experiment · KG edge: interacts_with
ATM Gene
gene · KG edge: interacts_with

Knowledge Graph (12 edges)

FANCC interacts_with FANCE
ATM interacts_with FANCE
FANCA interacts_with FANCE
FANCE contributes_to AIM2
FANCE interacts_with ATR
ATR interacts_with FANCE
AIM2 contributes_to FANCE
FANCE interacts_with FANCA
APOPTOSIS contributes_to FANCE
DNA interacts_with FANCE

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