Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about FANCE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | FANCE |
| Chromosome | 6p21.31 |
| Protein Type | Adaptor Protein |
| Function | encodes an essential adaptor protein that plays a critical role in the Fanconi anemia (FA) DNA repair pathway. |
| Molecular Weight | 44 kDa |
| Amino Acids | 396 aa |
| Ensembl ID | ENSG00000112039 |
| GeneCards | FANCE |
| Human Protein Atlas | FANCE |
| Human-Mouse | 85% identical at the amino acid level |
| Human-Zebrafish | 72% identical |
| Drosophila | Partial ortholog with 45% identity |
| Yeast | No clear ortholog (FA pathway is metazoan-specific) |
| Associated Diseases | neurodegeneration |
| Interactions | ATR, FANCA, P53, FANCC, ATM, DNA |
| KG Connections | 24 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
FANCE["<b>FANCE</b>"]
Als{"Als"}
FANCE -->|"contributes_to"| Als
Senescence{"Senescence"}
FANCE -->|"contributes_to"| Senescence
AIM2(["AIM2"])
FANCE -->|"contributes_to"| AIM2
ATR(["ATR"])
FANCE -->|"interacts_with"| ATR
Inflammasome["Inflammasome"]
FANCE -->|"contributes_to"| Inflammasome
Er_Stress["Er Stress"]
FANCE -->|"contributes_to"| Er_Stress
FANCC(["FANCC"])
FANCC -->|"interacts_with"| FANCE
APOPTOSIS(["APOPTOSIS"])
APOPTOSIS -->|"contributes_to"| FANCE
ATM(["ATM"])
ATM -->|"interacts_with"| FANCE
FANCA(["FANCA"])
FANCA -->|"interacts_with"| FANCE
style FANCE fill:#1a3a4a,stroke:#ce93d8,stroke-width:3px,color:#ce93d8| Target | Relation | Type | Str |
|---|---|---|---|
| Als | contributes_to | disease | 0.65 |
| Senescence | contributes_to | disease | 0.65 |
| AIM2 | contributes_to | gene | 0.60 |
| ATR | interacts_with | gene | 0.60 |
| FANCA | interacts_with | gene | 0.60 |
| Inflammasome | contributes_to | pathway | 0.60 |
| Er Stress | contributes_to | pathway | 0.60 |
| Apoptosis | contributes_to | pathway | 0.60 |
| Neuron | contributes_to | cell_type | 0.60 |
| CGAS-STING | contributes_to | gene | 0.60 |
| Dna Repair | interacts_with | pathway | 0.60 |
| Cgas-Sting | contributes_to | pathway | 0.60 |
| P53 | interacts_with | protein | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| FANCC | interacts_with | gene | 0.60 |
| ATM | interacts_with | gene | 0.60 |
| FANCA | interacts_with | gene | 0.60 |
| ATR | interacts_with | gene | 0.60 |
| AIM2 | contributes_to | gene | 0.60 |
| APOPTOSIS | contributes_to | gene | 0.60 |
| DNA | interacts_with | gene | 0.60 |
| CGAS-STING | contributes_to | gene | 0.60 |
| FANCI | interacts_with | gene | 0.60 |
| P53 | interacts_with | gene | 0.60 |
| PPM1D | interacts_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||