gene

FANCE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FANCE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

24Connections
0Hypotheses
0Analyses
13Outgoing
11Incoming

No summary available yet. View on Wiki →

🧬 Gene Info
Gene SymbolFANCE
Chromosome6p21.31
Protein TypeAdaptor Protein
Functionencodes an essential adaptor protein that plays a critical role in the Fanconi anemia (FA) DNA repair pathway.
Molecular Weight44 kDa
Amino Acids396 aa
Ensembl IDENSG00000112039
GeneCardsFANCE
Human Protein AtlasFANCE
Human-Mouse85% identical at the amino acid level
Human-Zebrafish72% identical
DrosophilaPartial ortholog with 45% identity
YeastNo clear ortholog (FA pathway is metazoan-specific)
Associated Diseasesneurodegeneration
InteractionsATR, FANCA, P53, FANCC, ATM, DNA
KG Connections24 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

fance

gene · 2416 words

FANCF Gene

gene · 2646 words

FANCC Gene

gene · 2477 words

FANCA Protein

protein · 2116 words

FANCA Gene

gene · 2115 words

FANCB Protein

protein · 1934 words

Pathway Diagram

graph TD
    FANCE["<b>FANCE</b>"]
    Als{"Als"}
    FANCE -->|"contributes_to"| Als
    Senescence{"Senescence"}
    FANCE -->|"contributes_to"| Senescence
    AIM2(["AIM2"])
    FANCE -->|"contributes_to"| AIM2
    ATR(["ATR"])
    FANCE -->|"interacts_with"| ATR
    Inflammasome["Inflammasome"]
    FANCE -->|"contributes_to"| Inflammasome
    Er_Stress["Er Stress"]
    FANCE -->|"contributes_to"| Er_Stress
    FANCC(["FANCC"])
    FANCC -->|"interacts_with"| FANCE
    APOPTOSIS(["APOPTOSIS"])
    APOPTOSIS -->|"contributes_to"| FANCE
    ATM(["ATM"])
    ATM -->|"interacts_with"| FANCE
    FANCA(["FANCA"])
    FANCA -->|"interacts_with"| FANCE
    style FANCE fill:#1a3a4a,stroke:#ce93d8,stroke-width:3px,color:#ce93d8

Outgoing (13)

TargetRelationTypeStr
Alscontributes_todisease0.65
Senescencecontributes_todisease0.65
AIM2contributes_togene0.60
ATRinteracts_withgene0.60
FANCAinteracts_withgene0.60

Incoming (11)

SourceRelationTypeStr
FANCCinteracts_withgene0.60
ATMinteracts_withgene0.60
FANCAinteracts_withgene0.60
ATRinteracts_withgene0.60
AIM2contributes_togene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found