Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about FANCA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
FANCA (Fanconi Anemia Group A): DNA repair gene implicated in neurodegeneration, Parkinson's disease, and genomic stability
| Gene Symbol | FANCA |
| Full Name | Fanconi Anemia Group A |
| Chromosome | 16q24.3 |
| Molecular Weight | 180 kDa |
| Amino Acids | 1635 aa |
| Exons | 43 |
| UniProt ID | [O15360](https://www.uniprot.org/uniprot/O15360) |
| Ensembl ID | ENSG00000188191 |
| OMIM | 607139 |
| GeneCards | FANCA |
| Human Protein Atlas | FANCA |
| Bone marrow | Highest expression, consistent with the essential role in hematopoiesis |
| Testis | High expression, reflecting ongoing spermatogenesis |
| Associated Diseases | Fanconi Anemia |
| Interactions | TUFM, FANCE, ATR, DNA, FANCI, P53 |
| KG Connections | 33 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
FANCA["<b>FANCA</b>"]
Als{"Als"}
FANCA -->|"interacts with"| Als
Cancer{"Cancer"}
FANCA -->|"interacts with"| Cancer
Tumor{"Tumor"}
FANCA -->|"interacts with"| Tumor
TUFM["TUFM"]
FANCA -->|"interacts with"| TUFM
Mitochondrial_Function(["Mitochondrial Function"])
FANCA -->|"interacts with"| Mitochondrial_Function
neurodegeneration["neurodegeneration"]
FANCA -->|"implicated in"| neurodegeneration
FANCD2["FANCD2"]
FANCD2 -->|"interacts with"| FANCA
style FANCA fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Fanconi Anemia | causes | disease | 0.90 |
| Als | interacts_with | disease | 0.65 |
| Cancer | interacts_with | disease | 0.65 |
| Tumor | interacts_with | disease | 0.65 |
| Als | contributes_to | disease | 0.65 |
| Senescence | contributes_to | disease | 0.65 |
| TUFM | interacts_with | gene | 0.60 |
| FANCE | interacts_with | gene | 0.60 |
| AIM2 | contributes_to | gene | 0.60 |
| ATR | interacts_with | gene | 0.60 |
| Mitochondrial Function | interacts_with | pathway | 0.60 |
| DNA | interacts_with | gene | 0.60 |
| CGAS-STING | contributes_to | gene | 0.60 |
| FANCI | interacts_with | gene | 0.60 |
| P53 | interacts_with | gene | 0.60 |
| PPM1D | interacts_with | gene | 0.60 |
| Inflammasome | contributes_to | pathway | 0.60 |
| Er Stress | contributes_to | pathway | 0.60 |
| Apoptosis | contributes_to | pathway | 0.60 |
| Neuron | contributes_to | cell_type | 0.60 |
| Dna Repair | interacts_with | pathway | 0.60 |
| Cgas-Sting | contributes_to | pathway | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| FANCD2 | interacts_with | gene | 0.60 |
| FANCC | interacts_with | gene | 0.60 |
| ATM | interacts_with | gene | 0.60 |
| ATR | interacts_with | gene | 0.60 |
| AIM2 | contributes_to | gene | 0.60 |
| FANCE | interacts_with | gene | 0.60 |
| APOPTOSIS | contributes_to | gene | 0.60 |
| FANCI | interacts_with | gene | 0.60 |
| PPM1D | interacts_with | gene | 0.60 |
| P53 | interacts_with | gene | 0.60 |
| DNA | interacts_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||