gene 1,438 words KG: GAS6 2026-03-26
kind:genesection:genesstate:publishedtopic:alzheimerstopic:parkinsons
Contents

GAS6 - Growth Arrest Specific 6

🧬 Gene Info
Gene SymbolGAS6
Full NameGrowth Arrest Specific 6
Chromosome13q34
Functionis a multifunctional protein involved in cell survival, proliferation, migration, phagocytosis, and immunomodulation.
PathwaysNf-Κb, Phagocytosis, Proteasome
UniProt ID[P14384](https://www.uniprot.org/uniprot/P14384)
Ensembl IDENSG00000111321
OMIM600441
GeneCardsGAS6
Human Protein AtlasGAS6
Gla Domainγ-carboxylated glutamic acid residues enable calcium-dependent membrane binding
Loop 1Contains growth factor-like domain with receptor binding sites
Loop 2Additional receptor interaction region
Loop 3Heparin-binding site for cell surface proteoglycan interaction
C-terminal RegionContains sex hormone-binding globulin (SHBG)-like domain
Associated DiseasesAPOPTOSIS, Aging, Alzheimer, Atherosclerosis, Cancer, Ms
InteractionsAPOE, TRAF6, APP, AXL, ALZHEIMER'S DISEASE, DEMENTIA
KG Connections112 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (17)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.36
TREM2-Dependent Microglial Senescence Transition
Score: 0.69
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
APOE-Dependent Autophagy Restoration
Score: 0.61
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59

Related Analyses (7)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Cell type vulnerability in Alzheimer's Disease (SEA-AD data)
neurodegeneration · failed

See Also (7)

Packard Center for ALS Research
institution · KG edge: activates
Alzheimer Indonesia
institution · KG edge: activates
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: activates
AXL - AXL Receptor Tyrosine Kinase
gene · KG edge: activates
Astrocytes
entity · KG edge: associated_with

Knowledge Graph (12 edges)

GAS6 inhibits APOE
GAS6 inhibits TRAF6
GAS6 associated_with UBIQUITIN
GAS6 activates APP
GAS6 activates AXL
GAS6 associated_with AXL
GAS6 regulates PPAR
GAS6 regulates cardiovascular disease
GAS6 inhibits AXL
GAS6 implicated_in Atherosclerosis