gene 2,567 words KG: GRID1
Contents

GRID1 — Glutamate Ionotropic Receptor Delta Type Subunit 1

🧬 Gene Info
Gene SymbolGRID1
Full NameGlutamate Ionotropic Receptor Delta Type Subunit 1
Protein TypeReceptor
FunctionGRID1 (Glutamate Receptor Ionotropic Delta 1), also known as GluRδ1, is a member of the ionotropic glutamate receptor family.
Primary ExpressionPrefrontal Cortex, Cortex, Ventral Tegmental Area, Substantia Nigra
PathwaysAutophagy
Ensembl IDENSG00000148677
GeneCardsGRID1
Human Protein AtlasGRID1
Ligand-binding domain (LBD)Contains the glutamate binding site (though ligand gating is non-functional)
Three transmembrane domainsForm the ion channel pore
Intracellular C-terminal tailContains phosphorylation sites and PDZ-binding motifs
Associated Diseasesneurodegeneration
InteractionsGLUD1, LAMP1, PRKCD, CBLN1, BECN1, MAP1LC3B
KG Connections36 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (1)

Lysosomal Positioning Dynamics Modulation
Score: 0.43

Related Analyses (2)

Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (12)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40
Neural Oscillation Dysfunction Validation in Parkinson's Dis
clinical · proposed · Score: 0.40

See Also (13)

Packard Center for ALS Research
institution · KG edge: expressed_in
slc17a7 Gene
gene · KG edge: expressed_in
PRKCD — Protein Kinase C Delta
gene · KG edge: inhibits
MAP1LC3B — LC3B
gene · KG edge: inhibits
Lysosomal Associated Membrane Protein 1 (LAMP1)
gene · KG edge: inhibits

Knowledge Graph (12 edges)

GRID1 interacts_with GLUD1
GRID1 inhibits LAMP1
GRID1 inhibits PRKCD
GRID1 inhibits CBLN1
GRID1 inhibits BECN1
GRID1 inhibits MAP1LC3B
GRID1 inhibits SQSTM1
GRID1 expressed_in SLC17A7
GRID1 expressed_in GRIN2B
GRID1 expressed_in Ventral Tegmental Area