gene 1,083 words KG: GLUD1 2026-03-24
kind:genesection:genesstate:published
Contents

GLUD1 - Glutamate Dehydrogenase 1

🧬 Gene Info
Gene SymbolGLUD1
Full NameGlutamate Dehydrogenase 1
AliasesPage for GLUD1
Chromosome10q23.3
Protein TypeEnzyme
FunctionGLUD1 is a mitochondrial matrix enzyme belonging to the glutamate dehydrogenase family
Primary ExpressionLiver, kidney, brain, pancreas
Amino Acids505 aa
PathwaysGlycolysis, Histone Modification, Mtor, Oxidative Phosphorylation, Oxidative Stress
UniProt ID[P00341](https://www.uniprot.org/uniprot/P00341)
Ensembl IDENSG00000148671
OMIM130120
GeneCardsGLUD1
Human Protein AtlasGLUD1
N-terminal antenna regionContains the allosteric binding sites
Associated DiseasesParkinson, Parkinson'S Disease
InteractionsLAMP1, PRKCD, CBLN1, BECN1, NRG1, NLGN2
KG Connections118 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (5)

Metabolic Switch Targeting for A1→A2 Repolarization
Score: 0.48
Lysosomal Positioning Dynamics Modulation
Score: 0.43
Metabolic Reprogramming via Microglial Glycolysis Inhibition
Score: 0.39
KDM6A-Mediated H3K27me3 Rejuvenation
Score: 0.38
Grid Cell-Specific Metabolic Reprogramming via IDH2 Enhancem
Score: 0.38

Related Analyses (3)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (5)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40
Epigenetic Dysregulation Validation in Parkinson's Disease
clinical · proposed · Score: 0.40
Levodopa-Induced Dyskinesias Mechanism — Experiment Design
validation · proposed · Score: 0.40
Multiscale Computational Modeling of Protein Aggregation Kin
validation · proposed · Score: 0.40
Synaptic Mitochondrial Resilience Enhancement for Parkinson'
validation · proposed · Score: 0.40

See Also (13)

Packard Center for ALS Research
institution · KG edge: expressed_in
GLI Gene Family
gene · KG edge: activates
ERBB4 Gene
gene · KG edge: inhibits
EGFR — Epidermal Growth Factor Receptor
gene · KG edge: regulates
DISC1 — Disrupted in Schizophrenia 1
gene · KG edge: inhibits

Knowledge Graph (12 edges)

GLUD1 inhibits LAMP1
GLUD1 inhibits PRKCD
GLUD1 interacts_with CBLN1
GLUD1 inhibits BECN1
GLUD1 inhibits NRG1
GLUD1 inhibits NLGN2
GLUD1 therapeutic_target SNCA
GLUD1 associated_with LRPPRC
GLUD1 associated_with NDUFS2
GLUD1 associated_with NDUFS1