gene 2,808 words KG: PRKCD 2026-03-27
kind:genesection:genesstate:published
Contents

PRKCD — Protein Kinase C Delta

🧬 Gene Info
Gene SymbolPRKCD
Full NameProtein Kinase C Delta
Chromosome1p36.11
Protein TypeSerine/Threonine Kinase
FunctionProtein kinase C delta (PKCδ) is a novel PKC isoform member of the protein kinase C family of serine/threonine kinases.
Primary Expressionneurons, astrocytes, microglia, and oligodendrocytes
Molecular Weight78 kDa
Amino Acids673 aa
PathwaysHifs
UniProt IDQ05639
NCBI Gene ID5580
Ensembl IDENSG00000163932
OMIM176977
GeneCardsPRKCD
Human Protein AtlasPRKCD
Associated DiseasesAls, Cancer, DNA fragmentation
InteractionsCBLN1, MAP1LC3B, SQSTM1, GLUD1, caspase-3, Akt
KG Connections51 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (4)

APOE-Dependent Autophagy Restoration
Score: 0.61
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Lysosomal Positioning Dynamics Modulation
Score: 0.43
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.42

Related Analyses (5)

Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived

See Also (15)

erk-mapk-signaling-neurodegeneration
mechanism · KG edge: causes
Packard Center for ALS Research
institution · KG edge: causes
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: associated_with
MAPK3 Gene - ERK1
gene · KG edge: therapeutic_target
MAPK1 Gene
gene · KG edge: therapeutic_target

Knowledge Graph (12 edges)

PRKCD inhibits CBLN1
PRKCD expressed_in BECN1
PRKCD inhibits MAP1LC3B
PRKCD expressed_in LAMP1
PRKCD inhibits SQSTM1
PRKCD inhibits GLUD1
PRKCD associated_with APP
PRKCD associated_with EGFR
PRKCD associated_with MAPK1
PRKCD associated_with ESR1