gene 1,602 words KG: HEXB
Contents

HEXB Gene - Hexosaminidase Beta

🧬 Gene Info
Gene SymbolHEXB
Full NameHexosaminidase Subunit Beta
AliasesPage for HEXB Gene
Chromosome5q13.3
FunctionThe beta subunit partners with the alpha subunit (from HEXA) to form hexosaminidase A (Hex A), or pairs with another beta subunit to form hexosaminidase B (Hex B)
Molecular Weight58.8 kDa
Amino Acids529 aa
PathwaysMTOR, NF-kB signaling, Oxidative Stress, lipid metabolism
UniProt IDP07604
NCBI Gene ID3074
Ensembl IDENSG00000213626
OMIM272800
GeneCardsHEXB
Human Protein AtlasHEXB
Associated DiseasesALS, disease, neurodegeneration, Sandhoff Disease
Known Drugs/Compoundsrapamycin
InteractionsACTB, AMPK, CTSB, CTSD, DEMENTIA, DNA
KG Connections98 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (5)

CYP46A1 Overexpression Gene Therapy
Score: 0.89
Blood-Brain Barrier SPM Shuttle System
Score: 0.75
Microglial Purinergic Reprogramming
Score: 0.70
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Lysosomal Positioning Dynamics Modulation
Score: 0.69

Related Analyses (5)

4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (12)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40
Neural Oscillation Dysfunction Validation in Parkinson's Dis
clinical · proposed · Score: 0.40

See Also (10)

GBA (Redirect)
redirect · KG edge: associated_with
HEXA (Redirect)
redirect · KG edge: associated_with
DNA Damage Repair Deficiency Validation Study in Parkin
experiment · KG edge: inhibits
Genes
index · KG edge: associated_with
CTSD — Cathepsin D
gene · KG edge: expressed_in

Knowledge Graph (12 edges)

LAMP1 associated_with HEXB
TFEB activates HEXB
HEXB causes neurodegeneration
HEXB causes microglial_activation
HEXB causes astrogliosis
TSC2 inhibits HEXB
HEXB inhibits MTOR
CGAS expressed_in HEXB
HEXB expressed_in GBA
HEXB expressed_in GLA

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