gene

CHRNE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CHRNE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

90Connections
0Hypotheses
0Analyses
50Outgoing
38Incoming

Summary

CHRNE is a gene implicated in neurodegeneration research. Key relationships include: associated with, implicated in. Associated with Als, Alzheimer, Ms. Connected to 12 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolCHRNE
Full NameCholinergic Receptor Nicotinic Epsilon Subunit
Chromosome17p13.2
FunctionCHRNE encodes the epsilon subunit of nicotinic receptors at the NMJ.
Primary Expressionthe brain and play roles in cognitive function, attention, and motor control
PathwaysWnt
UniProt ID[P30530](https://www.uniprot.org/uniprotkb/P30530/entry)
GeneCardsCHRNE
Human Protein AtlasCHRNE
Associated DiseasesALS, Alzheimer, Ms
InteractionsWNT11, TNFRSF1B, TNFRSF13C, MYO7A, WNT1, CYTOKINES
KG Connections90 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Wiki Pages (13)

Knowledge base pages for this entity

Canonical Page

CHRNE Gene

gene · 667 words

adra2b Gene

gene · 1915 words

WNT11 Gene

gene · 1577 words

SHARPIN — SHANK Associated RH Domain Interactor

gene · 1323 words

WNT1 Gene

gene · 1226 words

Renshaw Cells

cell · 1081 words

Pathway Diagram

graph TD
    CHRNE["<b>CHRNE</b>"]
    Ms{"Ms"}
    CHRNE -->|"associated with"| Ms
    Alzheimer{"Alzheimer"}
    CHRNE -->|"associated with"| Alzheimer
    Als{"Als"}
    CHRNE -->|"associated with"| Als
    AND["AND"]
    CHRNE -->|"associated with"| AND
    AMYLOID["AMYLOID"]
    CHRNE -->|"associated with"| AMYLOID
    neurodegeneration["neurodegeneration"]
    CHRNE -->|"implicated in"| neurodegeneration
    APP["APP"]
    APP -->|"associated with"| CHRNE
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    ALZHEIMER_S_DISEASE -->|"associated with"| CHRNE
    NDUFAF7["NDUFAF7"]
    NDUFAF7 -->|"associated with"| CHRNE
    SHARPIN["SHARPIN"]
    SHARPIN -->|"associated with"| CHRNE
    APOE["APOE"]
    APOE -->|"associated with"| CHRNE
    PLCG2["PLCG2"]
    PLCG2 -->|"associated with"| CHRNE
    ALZHEIMER["ALZHEIMER"]
    ALZHEIMER -->|"associated with"| CHRNE
    style CHRNE fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (52)

TargetRelationTypeStr
Msassociated_withdisease0.65
Alzheimerassociated_withdisease0.65
Alsassociated_withdisease0.65
Alsactivatesdisease0.65
ALSactivatesdisease0.65

Incoming (38)

SourceRelationTypeStr
APPassociated_withgene0.60
NDUFAF7associated_withgene0.60
SHARPINassociated_withgene0.60
APOEassociated_withgene0.60
PLCG2associated_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found