Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CHRNE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
CHRNE is a gene implicated in neurodegeneration research. Key relationships include: associated with, implicated in. Associated with Als, Alzheimer, Ms. Connected to 12 entities in the SciDEX knowledge graph.
| Gene Symbol | CHRNE |
| Full Name | Cholinergic Receptor Nicotinic Epsilon Subunit |
| Chromosome | 17p13.2 |
| Function | CHRNE encodes the epsilon subunit of nicotinic receptors at the NMJ. |
| Primary Expression | the brain and play roles in cognitive function, attention, and motor control |
| Pathways | Wnt |
| UniProt ID | [P30530](https://www.uniprot.org/uniprotkb/P30530/entry) |
| GeneCards | CHRNE |
| Human Protein Atlas | CHRNE |
| Associated Diseases | ALS, Alzheimer, Ms |
| Interactions | WNT11, TNFRSF1B, TNFRSF13C, MYO7A, WNT1, CYTOKINES |
| KG Connections | 90 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
CHRNE["<b>CHRNE</b>"]
Ms{"Ms"}
CHRNE -->|"associated with"| Ms
Alzheimer{"Alzheimer"}
CHRNE -->|"associated with"| Alzheimer
Als{"Als"}
CHRNE -->|"associated with"| Als
AND["AND"]
CHRNE -->|"associated with"| AND
AMYLOID["AMYLOID"]
CHRNE -->|"associated with"| AMYLOID
neurodegeneration["neurodegeneration"]
CHRNE -->|"implicated in"| neurodegeneration
APP["APP"]
APP -->|"associated with"| CHRNE
ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
ALZHEIMER_S_DISEASE -->|"associated with"| CHRNE
NDUFAF7["NDUFAF7"]
NDUFAF7 -->|"associated with"| CHRNE
SHARPIN["SHARPIN"]
SHARPIN -->|"associated with"| CHRNE
APOE["APOE"]
APOE -->|"associated with"| CHRNE
PLCG2["PLCG2"]
PLCG2 -->|"associated with"| CHRNE
ALZHEIMER["ALZHEIMER"]
ALZHEIMER -->|"associated with"| CHRNE
style CHRNE fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Ms | associated_with | disease | 0.65 |
| Alzheimer | associated_with | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Als | activates | disease | 0.65 |
| ALS | activates | disease | 0.65 |
| ALS | associated_with | disease | 0.65 |
| WNT11 | activates | gene | 0.60 |
| GRIN3B | expressed_in | gene | 0.60 |
| TNFRSF1B | activates | gene | 0.60 |
| TNFRSF13C | activates | gene | 0.60 |
| HCRTR1 | expressed_in | gene | 0.60 |
| APOE | associated_with | gene | 0.60 |
| CD33 | associated_with | gene | 0.60 |
| BIN1 | associated_with | gene | 0.60 |
| SPI1 | associated_with | gene | 0.60 |
| GRM2 | expressed_in | gene | 0.60 |
| CASS4 | associated_with | gene | 0.60 |
| CHRM4 | expressed_in | gene | 0.60 |
| MYO7A | activates | gene | 0.60 |
| ADRA2B | expressed_in | gene | 0.60 |
| CR1 | associated_with | gene | 0.60 |
| CLU | associated_with | gene | 0.60 |
| MS4A6A | associated_with | gene | 0.60 |
| WNT1 | activates | gene | 0.60 |
| Rb | expressed_in | protein | 0.60 |
| DES | causes | gene | 0.60 |
| AMYLOID | associated_with | gene | 0.60 |
| GABA | expressed_in | gene | 0.60 |
| CYTOKINES | activates | gene | 0.60 |
| Wnt | activates | pathway | 0.60 |
| Microglia | activates | cell_type | 0.60 |
| Astrocyte | activates | cell_type | 0.60 |
| MICROGLIA | associated_with | gene | 0.60 |
| Immune Response | associated_with | pathway | 0.60 |
| Monocyte | associated_with | cell_type | 0.60 |
| Microglia | associated_with | cell_type | 0.60 |
| AND | expressed_in | gene | 0.60 |
| GENES | activates | gene | 0.60 |
| ASTROCYTE | activates | gene | 0.60 |
| RNA | associated_with | gene | 0.60 |
| AND | associated_with | gene | 0.60 |
| ALZHEIMER'S DISEASE | associated_with | gene | 0.60 |
| HLA | associated_with | gene | 0.60 |
| Cytokine | activates | protein | 0.60 |
| Ras | causes | protein | 0.60 |
| Brainstem | expressed_in | brain_region | 0.55 |
| Astrocyte | expressed_in | cell_type | 0.55 |
| Microglia | expressed_in | cell_type | 0.55 |
| Ca1 | expressed_in | brain_region | 0.55 |
| CLU | co_expressed_with | gene | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| APP | associated_with | gene | 0.60 |
| NDUFAF7 | associated_with | gene | 0.60 |
| SHARPIN | associated_with | gene | 0.60 |
| APOE | associated_with | gene | 0.60 |
| PLCG2 | associated_with | gene | 0.60 |
| CHRM4 | expressed_in | gene | 0.60 |
| MYO7A | activates | gene | 0.60 |
| GRM2 | expressed_in | gene | 0.60 |
| WNT1 | activates | gene | 0.60 |
| CRH | expressed_in | gene | 0.60 |
| ADRA2B | expressed_in | gene | 0.60 |
| IL13 | activates | gene | 0.60 |
| CR1 | associated_with | gene | 0.60 |
| MS4A6A | associated_with | gene | 0.60 |
| CASS4 | associated_with | gene | 0.60 |
| CLU | associated_with | gene | 0.60 |
| TNFRSF1B | activates | gene | 0.60 |
| GRIN3B | expressed_in | gene | 0.60 |
| HCRTR1 | expressed_in | gene | 0.60 |
| WNT11 | activates | gene | 0.60 |
| BIN1 | associated_with | gene | 0.60 |
| SPI1 | associated_with | gene | 0.60 |
| TNFRSF13C | activates | gene | 0.60 |
| CD33 | associated_with | gene | 0.60 |
| MACF1 | causes | gene | 0.60 |
| ALZHEIMER'S DISEASE | associated_with | gene | 0.60 |
| ALZHEIMER | associated_with | gene | 0.60 |
| ASTROCYTE | activates | gene | 0.60 |
| WNT | activates | gene | 0.60 |
| CYTOKINES | activates | gene | 0.60 |
| GENES | associated_with | gene | 0.60 |
| APOE Ε4 | associated_with | gene | 0.60 |
| MICROGLIA | associated_with | gene | 0.60 |
| acetylcholine | expressed_in | disease | 0.50 |
| CASS4 | interacts_with | gene | 0.50 |
| CASS4 | co_expressed_with | gene | 0.50 |
| CD33 | co_expressed_with | gene | 0.50 |
| GABA | expressed_in | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||