gene 1,715 words KG: MRC1 2026-03-27
kind:genesection:genestopic:alzheimerstopic:neuroinflammationtopic:microgliatopic:immune-responsetopic:parkinsonsstate:published
Contents

MRC1 — Mannose Receptor C Type 1

🧬 Gene Info
Gene SymbolMRC1
Full NameMannose Receptor C Type 1 (CD206)
AliasesCD206
Chromosome10p12.33
Protein TypeReceptor
Functionencodes a C-type lectin receptor that plays a critical role in immune recognition and clearance of glycoproteins.
Molecular Weight175 kDa
Amino Acids1456 aa
Exons30
PathwaysImmune Response
UniProt ID[P22897](https://www.uniprot.org/uniprot/P22897)
Ensembl IDENSG00000138739
GeneCardsMRC1
Human Protein AtlasMRC1
Associated DiseasesAls, Cirrhosis, Fibrosis
InteractionsITGAM, CD14, JUN, CANCER, ICAM1, TLR2
KG Connections103 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (9)

TREM2-Dependent Microglial Senescence Transition
Score: 0.69
Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.62
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.52
TREM2-mediated microglial tau clearance enhancement
Score: 0.49
APOE-TREM2 Interaction Modulation
Score: 0.48

Related Analyses (5)

Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · completed

Related Experiments (2)

QTJD effects on macrophage polarization and inflammatory res
exploratory · proposed · Score: 0.95
Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (15)

Packard Center for ALS Research
institution · KG edge: associated_with
APOE contributes to Alzheimer's disease by regulating b
hypothesis · KG edge: associated_with
ICAM1 - Intercellular Adhesion Molecule 1
gene · KG edge: activates
HIF1A Gene - Hypoxia Inducible Factor 1 Subunit Alpha
gene · KG edge: associated_with
FGF2 — Fibroblast Growth Factor 2
gene · KG edge: associated_with

Knowledge Graph (12 edges)

MRC1 expressed_in IL1B
MRC1 activates ITGAM
MRC1 expressed_in TNF
MRC1 expressed_in CXCL2
MRC1 activates CD14
MRC1 expressed_in PPARG
MRC1 activates JUN
MRC1 regulates C1QB
MRC1 regulates CD38
MRC1 regulates CD163