gene

CHRM4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CHRM4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

45Connections

0Hypotheses

0Analyses

29Outgoing

16Incoming

Summary

CHRM4 (Cholinergic Receptor Muscarinic 4) - G protein-coupled receptor mediating cholinergic signaling in the brain. Role in cognitive function, Alzheimer's disease, and neurotransmitter modulation.

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🧬 Gene Info

Gene Symbol	CHRM4
Full Name	Cholinergic Receptor Muscarinic 4
Chromosome	11p12
Function	encodes a 479-amino acid protein.
Primary Expression	the brain, where it plays crucial roles in modulating cognitive function, motor control, and neurotransmitter systems
Amino Acids	479 aa
Pathways	Wnt
UniProt ID	[P48193](https://www.uniprot.org/uniprotkb/P48193/entry)
Ensembl ID	ENSG00000180720
GeneCards	CHRM4
Human Protein Atlas	CHRM4
Striatum	Highest expression in the striatum, particularly in the indirect pathway medium spiny neurons
Cortex	Moderate expression in layer 5 pyramidal neurons
Hippocampus	Expression in CA1-CA3 regions and dentate gyrus
Thalamus	Significant expression in thalamic nuclei
Associated Diseases	neurodegeneration
Interactions	MYO7A, WNT1, IL13, WNT11, TNFRSF1B, TNFRSF13C
KG Connections	45 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (17)

Knowledge base pages for this entity

Canonical Page

CHRM4 Gene

gene · 2720 words

→

A 52-Week, Open-Label Extension Study of ACP-204 in Adults With Alzheimer's D... (NCT06194799)

clinical · 3383 words

→

Pathway Diagram

graph TD
    CHRM4["CHRM4"]
    Als["Als"]
    MYO7A["MYO7A"]
    GRM2["GRM2"]
    WNT1["WNT1"]
    ASTROCYTE["ASTROCYTE"]
    CRH["CRH"]
    WNT["WNT"]
    ADRA2B["ADRA2B"]
    IL13["IL13"]
    CHRNE["CHRNE"]
    WNT11["WNT11"]
    GRIN3B["GRIN3B"]
    TNFRSF1B["TNFRSF1B"]
    GABA["GABA"]
    TNFRSF13C["TNFRSF13C"]
    HCRTR1["HCRTR1"]
    CYTOKINES["CYTOKINES"]
    Wnt["Wnt"]
    Microglia["Microglia"]
    Astrocyte["Astrocyte"]
    CHRM4 -->|"activates"| Als
    CHRM4 -->|"activates"| MYO7A
    CHRM4 -->|"expressed in"| GRM2
    CHRM4 -->|"activates"| WNT1
    CHRM4 -->|"activates"| ASTROCYTE
    CHRM4 -->|"expressed in"| CRH
    CHRM4 -->|"activates"| WNT
    CHRM4 -->|"expressed in"| ADRA2B
    CHRM4 -->|"activates"| IL13
    CHRM4 -->|"expressed in"| CHRNE
    CHRM4 -->|"activates"| WNT11
    CHRM4 -->|"expressed in"| GRIN3B
    CHRM4 -->|"activates"| TNFRSF1B
    CHRM4 -->|"expressed in"| GABA
    CHRM4 -->|"activates"| TNFRSF13C
    CHRM4 -->|"expressed in"| HCRTR1
    CHRM4 -->|"activates"| CYTOKINES
    CHRM4 -->|"activates"| Wnt
    CHRM4 -->|"activates"| Microglia
    CHRM4 -->|"activates"| Astrocyte
    style CHRM4 fill:#006494,stroke:#333,color:#e0e0e0,stroke-width:2px

Outgoing (29)

Target	Relation	Type	Str
Als	activates	disease	0.65
ALS	activates	disease	0.65
MYO7A	activates	gene	0.60
GRM2	expressed_in	gene	0.60
WNT1	activates	gene	0.60
CRH	expressed_in	gene	0.60
ADRA2B	expressed_in	gene	0.60
IL13	activates	gene	0.60
CHRNE	expressed_in	gene	0.60
WNT11	activates	gene	0.60
GRIN3B	expressed_in	gene	0.60
TNFRSF1B	activates	gene	0.60
TNFRSF13C	activates	gene	0.60
HCRTR1	expressed_in	gene	0.60
Rb	expressed_in	protein	0.60
ASTROCYTE	activates	gene	0.60
WNT	activates	gene	0.60
GABA	expressed_in	gene	0.60
CYTOKINES	activates	gene	0.60
Wnt	activates	pathway	0.60
Microglia	activates	cell_type	0.60
Astrocyte	activates	cell_type	0.60
AND	expressed_in	gene	0.60
GENES	activates	gene	0.60
Cytokine	activates	protein	0.60
Brainstem	expressed_in	brain_region	0.55
Astrocyte	expressed_in	cell_type	0.55
Microglia	expressed_in	cell_type	0.55
GLUTAMATE	expressed_in	concept	0.50

Incoming (16)

Source	Relation	Type	Str
WNT1	activates	gene	0.60
TNFRSF1B	activates	gene	0.60
GRIN3B	expressed_in	gene	0.60
CRH	expressed_in	gene	0.60
HCRTR1	expressed_in	gene	0.60
WNT11	activates	gene	0.60
MYO7A	activates	gene	0.60
IL13	activates	gene	0.60
CHRNE	expressed_in	gene	0.60
TNFRSF13C	activates	gene	0.60
GRM2	expressed_in	gene	0.60
CYTOKINES	activates	gene	0.60
WNT	activates	gene	0.60
ASTROCYTE	activates	gene	0.60
acetylcholine	expressed_in	disease	0.50
GABA	expressed_in	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

CHRM4

Understanding Entity Pages

Summary

Wiki Pages (17)

CHRM4 Gene

A 52-Week, Open-Label Extension Study of ACP-204 in Adults With Alzheimer's D... (NCT06194799)

karxt-nct07011745

DREADDs in Neurodegeneration

GRK5 — G Protein-Coupled Receptor Kinase 5

Muscarinic Acetylcholine Receptor M1 (CHRM1)

BAFFR Gene (TNFRSF13C)

nct06937229

WNT11 Gene

WNT1 Gene

TNFRSF1B Gene

Striatal Cholinergic Interneurons

CHRM2 — Muscarinic Acetylcholine Receptor M2

Muscarinic M4 Acetylcholine Receptor Neurons

Designer Receptors Exclusively Activated by Designer Drugs (DREADD) Neurons