| Gene Symbol | IL34 |
| Full Name | Interleukin 34 |
| Chromosome | 16q22.1 |
| Function | IL34 is a homodimeric cytokine that binds CSF1R with high affinity, driving microglial development and function. |
| Primary Expression | neurons and is implicated in neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, and multiple sclerosis |
| UniProt ID | Q86V25 |
| NCBI Gene ID | 146433 |
| Ensembl ID | ENSG00000157368 |
| OMIM | 612681 |
| GeneCards | IL34 |
| Human Protein Atlas | IL34 |
| Approach | Status |
| IL-34 protein | Preclinical |
| CSF1R agonists | Research |
| IL-34 neutralizers | Research |
| Associated Diseases | ALS, Alzheimer's disease, Parkinson's disease, neurodegeneration |
| Interactions | JAK2, STAT3 |
| KG Connections | 26 knowledge graph edges |
| Databases | GeneCardsHPASTRING |