gene 1,421 words KG: CR2 2026-03-28
kind:genesection:genesstate:published
Contents

CR2 (Complement Receptor Type 2)

🧬 Gene Info
Gene SymbolCR2
Full NameComplement Receptor Type 2 (CD21)
AliasesComplement Receptor Type 2, CD21
Chromosome1q32
Protein TypeReceptor
Functionis a membrane glycoprotein that serves as a primary receptor for fragments of complement component C3, particularly C3d, C3dg, and iC3b.
Primary Expressionsome tissues
Amino Acids1458 aa
Exons25
UniProt IDP08578
NCBI Gene ID1380
Ensembl IDENSG00000117322
OMIM120650
GeneCardsCR2
Human Protein AtlasCR2
Associated DiseasesALS, Alzheimer, Alzheimer's disease, Dementia, Ms, Parkinson's disease
InteractionsAQP4, ASTROCYTE, CYTOKINES, AND, ASTROCYTES, OLIGODENDROCYTE
KG Connections62 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (12)

SASP-Mediated Complement Cascade Amplification
Score: 0.70
Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.62
SASP-Driven Aquaporin-4 Dysregulation
Score: 0.59
Glymphatic System-Enhanced Antibody Clearance Reversal
Score: 0.54
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.52

Related Analyses (10)

Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed

See Also (11)

Packard Center for ALS Research
institution · KG edge: activates
Alzheimer Indonesia
institution · KG edge: associated_with
Autoimmune Hypothesis in Alzheimer's Disease
hypothesis · KG edge: activates
CTSH Gene
gene · KG edge: associated_with
CR1 Gene — Complement Component 1q Receptor
gene · KG edge: associated_with

Knowledge Graph (12 edges)

CR2 inhibits AQP4
CR2 associated_with TREM2
CR2 associated_with IL6
CR2 associated_with ZCWPW1
CR2 associated_with CTSH
CR2 associated_with PILRB
CR2 associated_with GBA
CR2 associated_with CR1
CR2 causes ERBB1
CR2 causes GPNMB